Gzma Gene Summary [Rat]
Predicted to enable protein homodimerization activity and serine-type endopeptidase activity. Predicted to be involved in several processes, including cytotoxic T cell pyroptotic cell death; granzyme-mediated programmed cell death signaling pathway; and negative regulation of endodeoxyribonuclease activity. Predicted to act upstream of or within response to bacterium. Predicted to be located in nucleus. Predicted to be active in cytoplasm and extracellular space. Orthologous to human GZMA (granzyme A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gzma |
| Official Name | granzyme A [Source:RGD Symbol;Acc:628640] |
| Ensembl ID | ENSRNOG00000010603 |
| Bio databases IDs | |
| Aliases | granzyme A |
| Synonyms | CTLA3, GRANZYME A, Grz a, Hf, Hf1, H factor, HFSP, SE1, TSP-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gzma often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- serine endopeptidase
- trypsin
- Tryp_SPc
- serine-type peptidase
- granzyme A
- peptidase
- active site
- protein homodimerization
- Domain of unknown function (DUF1986)
- protein binding
Pathways
Biological processes and signaling networks where the Gzma gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- septic shock
- diabetic nephropathy
- preeclampsia
- endometriosis
- adenoid cystic carcinoma
- adamantinomatous craniopharyngioma
- head and neck squamous cell cancer
- prostate cancer
role in cell
- synthesis in
- cell viability
- cell death
- apoptosis
- expression in
- activation in
- phosphorylation in
- molecular cleavage in
- damage in
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- intracellular space
- Nucleus
- Plasma Membrane
- endosomes
- immunological synapses
- granules
- cytotoxic granule
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gzma gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of DNA binding
- negative regulation of oxidoreductase activity
- response to bacterium
- immune response
- positive regulation of apoptotic process
- apoptotic process
- killing of cells of other organism
- pyroptosis
- negative regulation of endodeoxyribonuclease activity
- protein maturation
- proteolysis involved in cellular protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- serine-type endopeptidase activity