Il1rl2 Gene Summary [Rat]
Predicted to enable NAD+ nucleosidase activity, cyclic ADP-ribose generating and interleukin-1 receptor activity. Predicted to be involved in cell surface receptor signaling pathway and regulation of inflammatory response. Predicted to act upstream of or within several processes, including cytokine-mediated signaling pathway; positive regulation of T cell differentiation; and positive regulation of interleukin-6 production. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Orthologous to human IL1RL2 (interleukin 1 receptor like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il1rl2 |
| Official Name | interleukin 1 receptor-like 2 [Source:RGD Symbol;Acc:621782] |
| Ensembl ID | ENSRNOG00000014683 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor-like 2 |
| Synonyms | IL-1 R6, IL1RRP2, IL-36R, interleukin 1 receptor-like 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il1rl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- Immunoglobulin like
- SEFIR domain
- Immunoglobulin I-set domain
- cytokine receptor
- TIR domain
- interleukin-1 receptor
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Il1rl2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- STAT3 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- allergic asthma
- neoplasia
- ulcerative colitis
- psoriatic lesion
- hidradenitis suppurativa
- generalized pustular psoriasis
- psoriasis
- Crohn disease
- Netherton syndrome
role in cell
- proliferation
- growth
- expression in
- activation in
- production in
- migration
- binding in
- phosphorylation in
- differentiation
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il1rl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular defense response
- inflammatory response
- signal transduction
- innate immune response
- positive regulation of T cell differentiation
- regulation of inflammatory response
- interleukin-1-mediated signaling pathway
- positive regulation of interleukin-6 production
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- NAD+ nucleosidase activity
- interleukin-1 receptor activity
- interleukin-1, Type I, activating receptor activity