Plcd1 Gene Summary [Rat]
Enables several functions, including inositol 1,4,5 trisphosphate binding activity; phospholipid binding activity; and phosphoric ester hydrolase activity. Involved in several processes, including positive regulation of inositol trisphosphate biosynthetic process; positive regulation of norepinephrine secretion; and response to prostaglandin F. Located in mitochondrial membrane. Used to study congestive heart failure and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plcd1 |
| Official Name | phospholipase C, delta 1 [Source:RGD Symbol;Acc:3346] |
| Ensembl ID | ENSRNOG00000032238 |
| Bio databases IDs | |
| Aliases | phospholipase C, delta 1 |
| Synonyms | NDNC3, phospholipase C delta 1, phospholipase C, delta 1, phospholipase C δ 1, phospholipase C, δ 1, Plc1, PLCD, Plc Delta1, PLC-III |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plcd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- EFh_PI-PLC
- Phosphatidylinositol-specific phospholipase C, X domain
- EFh_SPARC_EC
- Phospholipase C, catalytic domain (part: domain X)
- EF hand
- phosphatidylinositol-4,5-bisphosphate binding
- Phospholipase C, catalytic domain (part: domain Y)
- phosphatase
- PH domain
- C2 domain
- Phosphatidylinositol-specific phospholipase C, Y domain
- phospholipid binding
- EF-hand domain pair
- calcium-dependent phospholipid binding
- enzyme binding
- calcium ion binding
- protein binding
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- Pleckstrin homology-like domain
- phosphoinositide phospholipase C
- binding protein
- Phosphoinositide-specific phospholipase C, efhand-like
- Protein kinase C conserved region 2 (CalB)
- Pleckstrin homology domain
Pathways
Biological processes and signaling networks where the Plcd1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Cellular Effects of Sildenafil (Viagra)
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endothelin-1 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gap Junction Signaling
- Glioblastoma Multiforme Signaling
- Leptin Signaling in Obesity
- Melatonin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Sphingosine-1-phosphate Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- UVA-Induced MAPK Signaling
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- bipolar disorder
- nonsyndromic congenital nail disorder type 3
- tumorigenesis
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- epidermal inclusion cyst
- hyperplasia
- alopecia
- trichilemmal cyst
role in cell
- proliferation
- signaling in
- apoptosis
- migration
- growth
- formation in
- production in
- expression in
- phosphorylation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane surface
- cellular membrane
- Plasma Membrane
- cytosol
- basolateral membrane
- mitochondrial membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plcd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylinositol-mediated signaling
- lipid catabolic process
- phosphatidylinositol metabolic process
- release of sequestered calcium ion into cytosol
- phospholipid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- calcium ion binding
- GTPase activating protein binding