Nfkb1 Gene Summary [Mouse]
Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and transcription coregulator activity. Involved in several processes, including B cell receptor signaling pathway; cellular response to virus; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to tumor necrosis factor; regulation of gene expression; and response to muscle stretch. Located in cytosol. Part of NF-kappaB p50/p65 complex and transcription regulator complex. Is active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including HTLV-1-associated myelopathy/tropical spastic paraparesis; carcinoma (multiple); common variable immunodeficiency 12; melanoma; and prostate cancer. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfkb1 |
| Official Name | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [Source:MGI Symbol;Acc:MGI:97312] |
| Ensembl ID | ENSMUSG00000028163 |
| Bio databases IDs | |
| Aliases | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
| Synonyms | CVID12, EBP-1, KBF1, NF-kappa-B, NF-kappa-B1, Nf kappa b DNA binding subunit, NF-kappabeta, NF KAPPA B subunit P50, NF-kB, NFKB subunit P105/P50, NF-κ-B, NF-κ-B1, Nf κ b DNA binding subunit, NF κ B subunit P50, NUCLEAR FACTOR KAPPA B DNA binding subunit, nuclear factor kappa B subunit 1, nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105, nuclear factor of κ light polypeptide gene enhancer in B cells 1, p105, NUCLEAR FACTOR κ B DNA binding subunit, nuclear factor κ B subunit 1, p105 Nfkb, p50 NF-kappaB, P50 nf κ b, P50/P105 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfkb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- transcription regulator
- Ankyrin repeats (many copies)
- cell penetrating signal sequence
- Rel homology dimerization domain
- heat shock protein binding
- transcription cofactor
- transcription activation domain
- transcription factor binding
- chromatin binding
- identical protein binding
- Ankyrin repeat
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- ankyrin repeats
- glycine rich domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- dimerization domain
- DNA binding domain
- nucleic acid binding
- IPT
- actinin binding
- signal response domain
- nuclear localization sequence
- Ankyrin repeats (3 copies)
- protein binding
- sequence-specific DNA binding
- DNA binding
- PEST domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- binding protein
- double-stranded DNA binding
- N-terminal sub-domain of the Rel homology domain (RHD)
- Death Domain Superfamily of protein-protein interaction domains
- transcription factor activity
Pathways
Biological processes and signaling networks where the Nfkb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Acute Myeloid Leukemia Signaling
- Acute Phase Response Signaling
- Adrenomedullin signaling pathway
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Androgen Signaling
- Angiopoietin Signaling
- Antioxidant Action of Vitamin C
- Apelin Endothelial Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Apoptosis Signaling
- April Mediated Signaling
- Aryl Hydrocarbon Receptor Signaling
- Atherosclerosis Signaling
- Autophagy
- B Cell Activating Factor Signaling
- B Cell Receptor Signaling
- BMP signaling pathway
- Breast Cancer Regulation by Stathmin1
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- LXR/RXR Activation
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary open-angle glaucoma
- diarrhea
- neoplasia
- COVID-19
- cerebral hemorrhage
- Huntington disease
- prostate cancer
- fibrosis
- interstitial fibrosis
- rheumatoid arthritis
phenotypes
- abnormal B cell physiology
- abnormal CD4-positive alpha-beta T cell physiology
- abnormal Peyer's patch T cell area morphology
- abnormal Peyer's patch follicle morphology
- abnormal Peyer's patch germinal center morphology
- abnormal bone marrow cell morphology/development
- abnormal calcium ion homeostasis
- abnormal class switch recombination
- abnormal cochlear inner hair cell morphology
- abnormal colon morphology
- abnormal cornea morphology
- abnormal cytokine secretion
- abnormal dendritic cell physiology
- abnormal humoral immune response
- abnormal inflammatory response
- abnormal inguinal lymph node morphology
- abnormal lymph organ size
- abnormal lymphocyte physiology
- abnormal macrophage physiology
- abnormal professional antigen presenting cell physiology
- abnormal skin condition
- absent inguinal lymph nodes
- cecum inflammation
- cochlear ganglion degeneration
- decreased B cell proliferation
- decreased B-1 B cell number
- decreased B-1a cell number
- decreased CD8-positive naive alpha-beta T cell number
- decreased IgA level
- decreased IgE level
- decreased IgG level
- decreased IgG1 level
- decreased IgG3 level
- decreased IgM level
- decreased NK T cell number
- decreased NK cell number
- decreased Peyer's patch number
- decreased T cell proliferation
- decreased central memory CD4-positive alpha-beta T cell number
- decreased circulating amylase level
- decreased circulating interleukin-2 level
- decreased circulating sodium level
- decreased cochlear nerve compound action potential
- decreased effector memory CD4-positive alpha-beta T cell number
- decreased erythrocyte cell number
- decreased immunoglobulin level
- decreased interleukin-1 beta secretion
- decreased interleukin-2 secretion
- decreased interleukin-4 secretion
- decreased interleukin-6 secretion
- decreased lean body mass
- decreased marginal zone B cell number
- decreased mean corpuscular hemoglobin concentration
- decreased memory T cell number
- decreased myeloid dendritic cell number
- decreased osteoclast cell number
- decreased regulatory T cell number
- decreased respiratory quotient
- decreased single-positive T cell number
- decreased susceptibility to Picornaviridae infection induced morbidity/mortality
- decreased susceptibility to autoimmune diabetes
- decreased thermal nociceptive threshold
- decreased tumor necrosis factor secretion
- diarrhea
- enlarged lymph nodes
- enlarged spleen
- extramedullary hematopoiesis
- impaired humoral immune response
- increased B cell proliferation
- increased IgE level
- increased IgG1 level
- increased apoptosis
- increased central memory CD8 positive alpha-beta T cell number
- increased circulating alkaline phosphatase level
- increased circulating free fatty acid level
- increased immunoglobulin level
- increased leukocyte cell number
- increased susceptibility to age-related hearing loss
- increased susceptibility to bacterial infection
- increased susceptibility to bacterial infection induced morbidity/mortality
- increased susceptibility to induced colitis
- increased susceptibility to noise-induced hearing loss
- increased thermal nociceptive threshold
- large intestinal inflammation
- lethargy
- liver inflammation
- lung inflammation
- lymphoid hyperplasia
- myeloid hyperplasia
- no abnormal phenotype detected
- peritoneal inflammation
- postnatal growth retardation
- premature death
- preweaning lethality incomplete penetrance
- rough coat
- small Peyer's patches
- small inguinal lymph nodes
role in cell
- cell viability
- migration
- expression in
- phosphorylation in
- growth
- activation in
- cell death
- formation in
- production in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- secretory granule lumen
- Cytoplasm
- Extracellular Space
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
- nuclear matrix
- chromatin
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfkb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- positive regulation of transcription initiation from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
- JNK cascade
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- inflammatory response
- negative regulation of calcidiol 1-monooxygenase activity
- cellular response to interleukin-6
- positive regulation of transcription, DNA-dependent
- apoptotic process
- negative regulation of vitamin D biosynthetic process
- cellular response to dsRNA
- cellular response to stress
- cellular response to tumor necrosis factor
- response to muscle stretch
- negative regulation of protein metabolic process
- cellular response to nicotine
- B cell receptor signaling pathway
- positive regulation of miRNA metabolic process
- mammary gland involution
- negative regulation of inflammatory response
- positive regulation of canonical Wnt receptor signaling pathway
- NIK/NF-kappaB cascade
- I-kappaB kinase/NF-kappaB cascade
- positive regulation of hyaluronan biosynthetic process
- regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- cellular response to mechanical stimulus
- cellular response to lipopolysaccharide
- negative regulation of apoptotic process
- innate immune response
- cellular response to interleukin-1
- negative regulation of cholesterol transport
- negative regulation of interleukin-12 production
- positive regulation of macrophage derived foam cell differentiation
- positive regulation of lipid storage
Cellular Component
Where in the cell the gene product is active
- specific granule lumen
- extracellular region
- chromatin
- nucleoplasm
- transcription factor complex
- nucleus
- cytoplasm
- mitochondrion
- NF-kappaB p50/p65 complex
- cytosol
- secretory granule lumen
- I-kappaB/NF-kappaB complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- actinin binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- sequence-specific DNA binding transcription factor activity
- transcription cofactor activity
- protein binding