CREB3L4 Gene Summary [Human]

This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Details

Type
Processed Transcript
Official Symbol
CREB3L4
Official Name
cAMP responsive element binding protein 3 like 4 [Source:HGNC Symbol;Acc:HGNC:18854]
Ensembl ID
ENSG00000143578
Bio databases IDs NCBI: 148327 Ensembl: ENSG00000143578
Aliases cAMP responsive element binding protein 3 like 4
Synonyms 1700012K17Rik, 5330432F22Rik, acre1, AIBZIP, ATCE1, cAMP responsive element binding protein 3-like 4, CREB3, CREB4, hJAL, JAL, TISP40
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CREB3L4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
  • transcription regulator
  • nucleic acid binding
  • Basic region leucine zipper
  • protein binding
  • sequence-specific DNA binding
  • DNA binding
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding
  • double-stranded DNA binding
  • transmembrane domain
  • bZIP
  • Cell division protein ZapB
  • basic region leucin zipper
  • HR1

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • cancer
  • non-insulin-dependent diabetes mellitus
regulated by
  • NFE2L2
  • metribolone
  • NFAT5
  • ORF1ab
  • NKX2-1
  • androgen
  • AZD8055
  • 3,4-dihydroxyphenylethanol
  • methylselenic acid
  • CREM
regulates
role in cell
  • number
  • quantity
  • abnormal morphology

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • Golgi Apparatus
  • Endoplasmic Reticulum
  • Mitochondria
  • cytosol
  • endoplasmic reticulum membrane
  • Golgi membrane
  • nucleoplasm
  • nuclear envelope
  • chromatin

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CREB3L4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • spermatogenesis
  • positive regulation of transcription from RNA polymerase II promoter
  • response to unfolded protein
  • regulation of transcription from RNA polymerase II promoter

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • nucleus
  • nuclear membrane
  • mitochondrion
  • Golgi apparatus
  • Golgi membrane
  • endoplasmic reticulum
  • chromatin
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  • sequence-specific DNA binding RNA polymerase II transcription factor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.