FZD1 Gene Summary [Human]
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FZD1 |
| Official Name | frizzled class receptor 1 [Source:HGNC Symbol;Acc:HGNC:4038] |
| Ensembl ID | ENSG00000157240 |
| Bio databases IDs | |
| Aliases | frizzled class receptor 1, Wnt receptor, frizzled, Drosophila, homolog of, 1 |
| Synonyms | Frizzled 1, frizzled class receptor 1, Frz, FZ-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FZD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- Wnt-protein binding
- intracellular loop
- Frizzled/Smoothened family membrane region
- frizzled binding
- Wnt receptor
- Fz domain
- protein binding
- receptor binding
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
- PDZ-domain binding
- Wnt binding domain
- cytoplasmic domain
- transmembrane domain
- cytoplasmic localization sequence
- protein homodimerization
- intracellular domain
- PDZ binding motif
- cysteine rich domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the FZD1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Basal Cell Carcinoma Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- CREB Signaling in Neurons
- Factors Promoting Cardiogenesis in Vertebrates
- G-Protein Coupled Receptor Signaling
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Neuroinflammation Signaling Pathway
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- Wnt/Ca+ pathway
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
- breast carcinoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- glioblastoma
- natural killer cell neoplasia
- organismal death
- Cornelia de Lange syndrome
- cervical cancer
role in cell
- transcription in
- differentiation
- formation
- induction in
- accumulation in
- assembly
- signaling in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FZD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hard palate development
- planar cell polarity pathway involved in neural tube closure
- G-protein coupled receptor signaling pathway
- neuron differentiation
- muscular septum morphogenesis
- outflow tract morphogenesis
- cell-cell signaling
- endothelial cell differentiation
- response to xenobiotic stimulus
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of osteoblast differentiation
- canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation
- negative regulation of BMP signaling pathway
- negative regulation of canonical Wnt receptor signaling pathway
- membranous septum morphogenesis
- regulation of mesenchymal stem cell differentiation
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of protein phosphorylation
- canonical Wnt receptor signaling pathway
- positive regulation of neuron projection development
- non-canonical Wnt receptor signaling pathway
- autocrine signaling
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- Wnt-activated receptor activity
- frizzled binding
- protein binding
- PDZ domain binding
- Wnt-protein binding
- receptor binding