MIR223 Gene Summary [Human]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | MIR223 |
| Official Name | microRNA 223 [Source:HGNC Symbol;Acc:HGNC:31603] |
| Ensembl ID | ENSG00000284567 |
| Bio databases IDs | |
| Aliases | microRNA 223 |
| Synonyms | hsa-miR-223, microRNA 223, MIR233, MIRN223, miRNA223, mmu-miR-223, rno-miR-223 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIR223 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
- RNA binding
Pathways
Biological processes and signaling networks where the MIR223 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- neoplasia
- liver cancer
- epithelial cancer
- endometriosis
- breast cancer
- colorectal cancer
- experimental autoimmune encephalomyelitis
- limb-girdle muscular dystrophy type 2A
- enteritis
role in cell
- phosphorylation in
- expression in
- apoptosis
- activation in
- proliferation
- cell viability
- function
- growth
- production in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- blood microparticle
- Extracellular Space
- perinuclear region
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIR223 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Rho protein signal transduction
- regulation of macrophage differentiation
- regulation of dendritic cell differentiation
- gene silencing by miRNA
- negative regulation of inflammatory response
- negative regulation of neutrophil chemotaxis
- positive regulation of glucose import
- defense response to bacterium
- negative regulation of necroptosis
- inflammatory response
- response to hypoxia
- cellular response to lipopolysaccharide
- positive regulation of gene expression
- negative regulation of high-density lipoprotein particle clearance
- mRNA cleavage involved in gene silencing by miRNA
Cellular Component
Where in the cell the gene product is active
- extracellular space
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR binding