Trib2 Gene Summary [Mouse]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase regulator activity. Involved in negative regulation of fat cell differentiation and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and integumental system. Used to study Alzheimer's disease. Orthologous to human TRIB2 (tribbles pseudokinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trib2 |
| Official Name | tribbles pseudokinase 2 [Source:MGI Symbol;Acc:MGI:2145021] |
| Ensembl ID | ENSMUSG00000020601 |
| Bio databases IDs | |
| Aliases | tribbles pseudokinase 2 |
| Synonyms | C5FW, GS3955, LOC108351208, LOC686423, LOC690207, RGD1564451, TRB-2, tribbles pseudokinase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trib2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- ubiquitin protein ligase binding
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- transcription factor binding
- protein binding
- enzyme regulator activity
- Protein kinase domain
Pathways
Biological processes and signaling networks where the Trib2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cataract
role in cell
- production in
- phosphorylation in
- transmembrane potential
- proliferation
- apoptosis
- survival
- migration
- cell viability
- morphology
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoskeleton
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trib2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAP kinase activity
- negative regulation of interleukin-10 production
- negative regulation of fat cell differentiation
- protein phosphorylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- protein binding
- ubiquitin protein ligase binding
- protein kinase activity
- ubiquitin-protein ligase regulator activity
- protein kinase inhibitor activity
- mitogen-activated protein kinase kinase binding