Camk2g Gene Summary [Rat]
Enables calcium/calmodulin-dependent protein kinase activity. Involved in several processes, including protein autophosphorylation; regulation of protein localization to plasma membrane; and response to hypoxia. Is active in glutamatergic synapse and postsynaptic cytosol. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 59. Orthologous to human CAMK2G (calcium/calmodulin dependent protein kinase II gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Camk2g |
| Official Name | calcium/calmodulin-dependent protein kinase II gamma [Source:RGD Symbol;Acc:621802] |
| Ensembl ID | ENSRNOG00000009783 |
| Bio databases IDs | |
| Aliases | calcium/calmodulin-dependent protein kinase II gamma |
| Synonyms | calcium/calmodulin-dependent protein kinase II gamma, calcium/calmodulin-dependent protein kinase II γ, CAMK, CAMK2G B, CAMKG, CAMK-II, Camkii gamma, Camkii γ, CaM kinase II γ, LOC100909586, MRD59 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Camk2g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- SnoaL-like domain
- protein binding
- Protein kinase domain
- identical protein binding
- calmodulin regulated protein kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- protein homodimerization
- NTF2_like
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Camk2g gene in rat plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Calcium Signaling
- Chemokine Signaling
- Circadian Rhythm Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Factors Promoting Cardiogenesis in Vertebrates
- Glioma Signaling
- GM-CSF Signaling
- GNRH Signaling
- HIF1α Signaling
- Melatonin Signaling
- Molecular Mechanisms of Cancer
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Opioid Signaling Pathway
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- Reelin Signaling in Neurons
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- interstitial fibrosis
- liver cancer
- autosomal dominant intellectual developmental disorder type 59
- pervasive developmental disorder
- left ventricular dysfunction
- psoriasis
- cardiac hypertrophy
- asthma
- chronic obstructive pulmonary disease
role in cell
- apoptosis
- activation in
- cell death
- phosphorylation in
- proliferation
- synthesis in
- survival
- expression in
- quantity
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- endocytic vesicle membrane
- Nucleus
- cytosol
- nucleoplasm
- sarcoplasmic reticulum membrane
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Camk2g gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin secretion
- cell differentiation
- nervous system development
- regulation of neuron projection development
- regulation of calcium ion transport
- regulation of skeletal muscle adaptation
Cellular Component
Where in the cell the gene product is active
- calcium- and calmodulin-dependent protein kinase complex
- cytoplasm
- membrane
- cytosol
- neuron projection
- endocytic vesicle membrane
- sarcoplasmic reticulum membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- identical protein binding
- protein homodimerization activity
- protein binding
- calcium-dependent protein serine/threonine phosphatase activity
- calmodulin-dependent protein kinase activity