Fzd4

Enables Wnt receptor activity; Wnt-protein binding activity; and cytokine binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of neuron projection arborization; and vasculature development. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of signal transduction; and vasculature development. Located in cell-cell junction; dendrite; and plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Used to study Norrie disease and exudative vitreoretinopathy. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fzd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Fzd4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Fzd4 gene, providing context for its role in the cell.