TUSC3 Gene Summary [Mouse]
Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in cognition; magnesium ion transport; and protein N-linked glycosylation via asparagine. Located in mitochondrion. Is expressed in nervous system; neural retina; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 7. Orthologous to human TUSC3 (tumor suppressor candidate 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | TUSC3 |
| Official Name | tumor suppressor candidate 3 [Source:NCBI gene (formerly Entrezgene);Acc:80286] |
| Ensembl ID | ENSMUSG00000118664 |
| Bio databases IDs | |
| Aliases | tumor suppressor candidate 3 |
| Synonyms | D8S1992, LOC124902061, M33, MagT2, MRT22, MRT7, N33, OST3A, SLC58A2, tumor suppressor candidate 3, tumour suppressor candidate 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tusc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- magnesium ion transporter
- OST3 / OST6 family, transporter family
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- metabolic syndrome X
- autosomal recessive mental retardation type 7
- ETV6-RUNX1 positive B-lineage acute lymphoblastic leukemia
- hepatocellular carcinoma
- liver cancer
- mental retardation
- diabetic nephropathy
- autosomal recessive mental retardation
- hereditary disorder
role in cell
- migration
- growth
- expression in
- proliferation
- phosphorylation in
- apoptosis
- epithelial-mesenchymal transition
- N-glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- Mitochondria
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tusc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- cognition
- magnesium ion transport
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- oligosaccharyltransferase complex
- mitochondrion
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion transmembrane transporter activity