Plcb4 Gene Summary [Mouse]
Predicted to enable mitogen-activated protein kinase binding activity and phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Involved in modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; postsynaptic density; and smooth endoplasmic reticulum. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLCB4 (phospholipase C beta 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Plcb4 |
| Official Name | phospholipase C, beta 4 [Source:MGI Symbol;Acc:MGI:107464] |
| Ensembl ID | ENSMUSG00000039943 |
| Bio databases IDs | |
| Aliases | phospholipase C, beta 4 |
| Synonyms | A930039J07RIK, AI854601, ARCND2, ARCND2A, ARCND2B, Beta4aa, C230058B11RIK, phospholipase C beta 4, phospholipase C, beta 4, phospholipase C β 4, phospholipase C, β 4, PI-PLC, RATBETA4AA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plcb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphatidylinositol-specific phospholipase C, Y domain
- polo kinase kinase
- protein kinase binding
- enzyme
- phospholipase C
- protein binding
- Pleckstrin homology-like domain
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- PLC-beta C terminal
- Protein of unknown function (DUF1154)
- G-box domain
- EFh_PI-PLC
- phosphoinositide phospholipase C
- Phosphatidylinositol-specific phospholipase C, X domain
- P-box
- Phospholipase C, catalytic domain (part: domain X)
- Phosphoinositide-specific phospholipase C, efhand-like
- Phospholipase C, catalytic domain (part: domain Y)
- PH domain
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Pathways
Biological processes and signaling networks where the Plcb4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac Hypertrophy Signaling
- CCR3 Signaling in Eosinophils
- Cellular Effects of Sildenafil (Viagra)
- Chemokine Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- fMLP Signaling in Neutrophils
- Gαq Signaling
- Huntington's Disease Signaling
- Leptin Signaling in Obesity
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- Sphingosine-1-phosphate Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- metastasis
- neoplasia
- ataxia
- epithelial cancer
- auriculocondylar syndrome type 2B
- auriculocondylar syndrome type 2A
- endometriosis
- hereditary disorder
- gait disturbance
role in cell
- phosphorylation in
- production in
- proliferation
- electrophysiology
- long term synaptic depression
- abnormal morphology
- activation
- binding in
- accumulation in
- calcium response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- Nucleus
- Plasma Membrane
- cytosol
- smooth endoplasmatic reticulum
- perikaryon
- dendrites
- postsynaptic density
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plcb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- phosphatidylinositol-mediated signaling
- lipid catabolic process
- phosphatidylinositol metabolic process
- release of sequestered calcium ion into cytosol
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- calcium ion binding
- phospholipase C activity