Stat2

Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and ubiquitin-like protein ligase binding activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of type I interferon-mediated signaling pathway; and regulation of primary metabolic process. Predicted to be located in cytosol and plasma membrane. Predicted to be part of ISGF3 complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Zika fever; immunodeficiency 44; and neutropenia. Orthologous to human STAT2 (signal transducer and activator of transcription 2). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Stat2 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Stat2 gene, providing context for its role in the cell.