Efhd2 Gene Summary [Mouse]
Enables calcium ion binding activity. Predicted to be located in membrane raft. Is expressed in brain; embryo endoderm; extraembryonic component; gut; and heart. Orthologous to human EFHD2 (EF-hand domain family member D2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Efhd2 |
| Official Name | EF hand domain containing 2 [Source:MGI Symbol;Acc:MGI:106504] |
| Ensembl ID | ENSMUSG00000040659 |
| Bio databases IDs | |
| Aliases | EF hand domain containing 2 |
| Synonyms | 2600015J22Rik, D4WSU27E, EF hand domain containing 2, EF-hand domain family member D2, EF-hand domain family, member D2, Swip1, SWS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Efhd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain
- EF hand
- EF-hand domain pair
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- calcium ion binding
- EFh
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- alcoholic pancreatitis
- organismal death
role in cell
- expression in
- migration
- invasion by
- association
- endocytosis by
- tyrosine phosphorylation in
- association in
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Efhd2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- membrane raft
Molecular Function
What the gene product does at the molecular level
- cadherin binding
- calcium ion binding