Itgad Gene Summary [Mouse]
Predicted to enable integrin binding activity. Acts upstream of or within activated T cell proliferation. Predicted to be part of integrin complex. Predicted to be active in external side of plasma membrane. Orthologous to human ITGAD (integrin subunit alpha D). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itgad |
| Official Name | integrin, alpha D [Source:MGI Symbol;Acc:MGI:3578624] |
| Ensembl ID | ENSMUSG00000070369 |
| Bio databases IDs | |
| Aliases | integrin, alpha D |
| Synonyms | ADB2, CD11D, integrin, alpha D, integrin subunit alpha D, integrin subunit α D, integrin, α D, Itgax |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itgad often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin alpha (beta-propellor repeats)
- Integrin alpha cytoplasmic region
- extracellular domain
- binding protein
- von Willebrand factor (vWF) type A domain
- vWFA
- von Willebrand factor type A domain
- inserted domain
- FG-GAP repeat
- alpha1 domain
Pathways
Biological processes and signaling networks where the Itgad gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Cdc42 Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HGF Signaling
- Integrin Signaling
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- PAK Signaling
- Paxillin Signaling
- PI3K/AKT Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- COVID-19
- renal glucosuria
- lung cancer
- diabetic nephropathy
- infection by parasite
- infection by bacteria
role in cell
- activation
- proliferation
- accumulation
- binding
- accumulation in
- adhesion
- quantity
- number
- function
- transmigration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itgad gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- integrin-mediated signaling pathway
- cell adhesion mediated by integrin
- immune response
- heterotypic cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- integrin complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- integrin binding