Wnt9a Gene Summary [Rat]
Predicted to enable cytokine activity and frizzled binding activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway; negative regulation of cell population proliferation; and neuron differentiation. Predicted to act upstream of or within several processes, including embryonic morphogenesis; negative regulation of chondrocyte differentiation; and positive regulation of smoothened signaling pathway. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human WNT9A (Wnt family member 9A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnt9a |
| Official Name | Wnt family member 9A [Source:RGD Symbol;Acc:1305018] |
| Ensembl ID | ENSRNOG00000003066 |
| Bio databases IDs | |
| Aliases | Wnt family member 9A |
| Synonyms | wingless-type MMTV integration site family, member 9A, WNT14, Wnt family member 9A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wnt9a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- wnt family
- receptor agonist activity
- protein binding
- found in Wnt-1
Pathways
Biological processes and signaling networks where the Wnt9a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- hypoplasia
- colorectal cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- proliferation
- apoptosis
- differentiation
- replication in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wnt9a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- embryonic skeletal joint development
- cellular response to retinoic acid
- negative regulation of cell proliferation
- cell fate commitment
- canonical Wnt receptor signaling pathway
- negative regulation of chondrocyte differentiation
- iris morphogenesis
- cornea development in camera-type eye
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein binding
- receptor agonist activity
- cytokine activity