WNT9A Gene Summary [Human]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
WNT9A
Official Name
Wnt family member 9A [Source:HGNC Symbol;Acc:HGNC:12778]
Ensembl ID
ENSG00000143816
Bio databases IDs NCBI: 7483 Ensembl: ENSG00000143816
Aliases Wnt family member 9A
Synonyms wingless-type MMTV integration site family, member 9A, WNT14, Wnt family member 9A
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WNT9A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Wnt
  • wnt family
  • receptor agonist activity
  • protein binding
  • found in Wnt-1

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • rheumatoid arthritis
  • hypoplasia
  • colorectal cancer
  • lung adenocarcinoma
  • lung adenocarcinoma formation
regulated by
role in cell
  • proliferation
  • apoptosis
  • differentiation
  • replication in
  • function

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • extracellular matrix

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human WNT9A gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • neuron differentiation
  • embryonic skeletal joint development
  • cellular response to retinoic acid
  • negative regulation of cell proliferation
  • cell fate commitment
  • canonical Wnt receptor signaling pathway
  • negative regulation of chondrocyte differentiation
  • iris morphogenesis
  • cornea development in camera-type eye

Cellular Component

Where in the cell the gene product is active
  • extracellular space
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • frizzled binding
  • protein binding
  • receptor agonist activity
  • cytokine activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.