Itgb8 Gene Summary [Rat]
Enables signaling receptor binding activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; regulation of gene expression; and vasculogenesis. Predicted to act upstream of or within several processes, including Langerhans cell differentiation; hard palate development; and transforming growth factor beta receptor signaling pathway. Predicted to be part of integrin alphav-beta8 complex. Predicted to be active in cell surface and focal adhesion. Orthologous to human ITGB8 (integrin subunit beta 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itgb8 |
| Official Name | integrin subunit beta 8 [Source:RGD Symbol;Acc:1311374] |
| Ensembl ID | ENSRNOG00000006569 |
| Bio databases IDs | |
| Aliases | integrin subunit beta 8 |
| Synonyms | 4832412O06RIK, Integrin beta8, integrin subunit beta 8, integrin subunit β 8, integrin β 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itgb8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin beta chain VWA domain
- cytoplasmic domain
- Integrin plexin domain
- vWFA
- protein binding
- receptor binding
- cytosolic tail domain
- Integrin beta subunits (N-terminal portion of extracellular region)
Pathways
Biological processes and signaling networks where the Itgb8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- ILK Signaling
- Integrin Signaling
- Macropinocytosis Signaling
- PAK Signaling
- Paxillin Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Tec Kinase Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- experimental autoimmune encephalomyelitis
- allergic rhinitis
- atopic dermatitis
- epithelial cancer
- prostate cancer
- rheumatoid arthritis
- primary biliary cirrhosis
- insulin-dependent diabetes mellitus
- motor dysfunction
role in cell
- proliferation
- binding
- phosphorylation in
- expression in
- migration
- differentiation
- loss
- formation
- number
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell-matrix contacts
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itgb8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- hard palate development
- placenta blood vessel development
- transforming growth factor beta receptor signaling pathway
- cell adhesion
- vasculogenesis
- response to virus
- positive regulation of angiogenesis
- ganglioside metabolic process
- negative regulation of gene expression
- cell adhesion mediated by integrin
- integrin-mediated signaling pathway
- immune response
- positive regulation of gene expression
- cell migration
- cartilage development
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- alphav-beta8 integrin complex
- integrin complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- integrin binding