Adcy1 Gene Summary [Rat]
Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in cAMP biosynthetic process; circadian rhythm; and response to xenobiotic stimulus. Located in axon hillock; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44. Orthologous to human ADCY1 (adenylate cyclase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adcy1 |
| Official Name | adenylate cyclase 1 [Source:RGD Symbol;Acc:1309318] |
| Ensembl ID | ENSRNOG00000059479 |
| Bio databases IDs | |
| Aliases | adenylate cyclase 1 |
| Synonyms | AC1, adenylate cyclase 1, brl, D11Bwg1392e, D4A3N4, DFNB44, I-AC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adcy1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- adenylate cyclase
- calcium/calmodulin-responsive adenylate cyclase
- C1A domain
- Class III nucleotidyl cyclases
- enzyme
- Adenylyl- / guanylyl cyclase, catalytic domain
Pathways
Biological processes and signaling networks where the Adcy1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Adipocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- G Beta Gamma Signaling
- Gustation Pathway
- Hepatic Cholestasis
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Protein Kinase A Signaling
- Renin-Angiotensin Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- schizophrenia
- androgenic alopecia
- autosomal recessive deafness type 44
- mechanical hyperalgesia
- hyperactive behavior
- Duchenne muscular dystrophy
- familial nonsyndromic hearing impairment
- memory deficits
role in cell
- activation in
- apoptosis
- growth
- cell viability
- production in
- response
- long-term potentiation
- development
- long-term potentiation in
- elevation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cellular membrane
- Nucleus
- apical membrane
- synaptic membrane
- axon hillock
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adcy1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-term memory
- cAMP biosynthetic process
- cellular response to calcium ion
- positive regulation of long-term synaptic potentiation
- axonogenesis
- positive regulation of CREB transcription factor activity
- response to xenobiotic stimulus
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- regulation of circadian rhythm
- circadian rhythm
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane raft
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium- and calmodulin-responsive adenylate cyclase activity
- ATP binding
- calmodulin binding
- metal ion binding
- adenylate cyclase activity