Rxra Gene Summary [Mouse]
Enables DNA binding activity; DNA-binding transcription factor activity; and transcription coactivator binding activity. Contributes to nuclear receptor activity and transcription cis-regulatory region binding activity. Involved in several processes, including mRNA transcription by RNA polymerase II; positive regulation of thyroid hormone receptor signaling pathway; and retinoic acid receptor signaling pathway. Acts upstream of or within several processes, including cardiac muscle tissue development; regulation of branching involved in prostate gland morphogenesis; and regulation of gene expression. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and sensory organ. Used to study congenital heart disease; dilated cardiomyopathy; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RXRA (retinoid X receptor alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rxra |
| Official Name | retinoid X receptor alpha [Source:MGI Symbol;Acc:MGI:98214] |
| Ensembl ID | ENSMUSG00000015846 |
| Bio databases IDs | |
| Aliases | retinoid X receptor alpha |
| Synonyms | 9530071D11RIK, LOC101928454, NR2B1, retinoid 10 receptor α, Retinoid X receptor alpha, Retinoid X receptor α, RXR-alpha, RXRalpha1, RXR-α, Rxr α 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rxra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- steroid hormone receptor
- A/B region
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- retinoic acid receptor binding
- transcription activation domain
- transcription factor binding
- AF-2 transcription activation domain
- chromatin binding
- TA box
- retinoid binding
- identical protein binding
- hormone binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- nuclear receptor ligand binding domain
- P-box
- AF-1 domain
- zinc ion binding
- ligand-binding domain
- ligand-dependent nuclear receptor
- RXRalpha ABC domain
- T-box domain
- Jnk phosphorylation site
- dimerization domain
- DBD domain binding
- DNA binding domain
- nucleic acid binding
- vitamin D receptor binding
- enzyme binding
- protein domain specific binding
- protein binding
- thyroid hormone receptor binding
- LBD domain binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- Nuclear/hormone receptor activator site AF-1
- binding protein
- double-stranded DNA binding
- hinge domain
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the Rxra gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Aryl Hydrocarbon Receptor Signaling
- Docosahexaenoic Acid (DHA) Signaling
- FXR/RXR Activation
- Glucocorticoid Receptor Signaling
- Hepatic Cholestasis
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Non-Small Cell Lung Cancer Signaling
- Nur77 Signaling in T Lymphocytes
- PPAR Signaling
- PPARα/RXRα Activation
- PXR/RXR Activation
- RAR Activation
- Retinoic acid Mediated Apoptosis Signaling
- Small Cell Lung Cancer Signaling
- TR/RXR Activation
- VDR/RXR Activation
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- epithelial cancer
- cancer
- neoplasia
- plasma cell myeloma
- skin cancer
- eczema
- retinitis pigmentosa
- type M3 acute myeloid leukemia
- acne vulgaris
phenotypes
- abnormal T-helper 2 cell morphology
- abnormal atrioventricular cushion morphology
- abnormal atrioventricular valve morphology
- abnormal axial skeleton morphology
- abnormal cardiovascular system morphology
- abnormal conotruncal ridge morphology
- abnormal conotruncus septation
- abnormal corneal stroma morphology
- abnormal cricoid cartilage morphology
- abnormal dendritic cell physiology
- abnormal digit morphology
- abnormal epidermis stratum corneum morphology
- abnormal extraembryonic tissue morphology
- abnormal eye development
- abnormal eye morphology
- abnormal eyelid morphology
- abnormal heart development
- abnormal heart left atrium morphology
- abnormal heart morphology
- abnormal heart ventricle morphology
- abnormal interventricular septum morphology
- abnormal keratinocyte morphology
- abnormal mitral valve morphology
- abnormal myocardial trabeculae morphology
- abnormal myocardium compact layer morphology
- abnormal myocardium layer morphology
- abnormal ocular fundus morphology
- abnormal optic disk morphology
- abnormal pericardial cavity morphology
- abnormal pericardium morphology
- abnormal pharyngeal arch artery morphology
- abnormal placenta labyrinth morphology
- abnormal placenta morphology
- abnormal postnatal growth/weight/body size
- abnormal regulatory T cell physiology
- abnormal skeleton development
- abnormal skin condition
- abnormal skin morphology
- abnormal tricuspid valve morphology
- abnormal truncus arteriosus septation
- abnormal vasculogenesis
- abnormal ventricle papillary muscle morphology
- absent Harderian gland
- absent sclera
- absent sublingual duct
- alopecia
- aortopulmonary window
- atrioventricular block
- complete atrioventricular septal defect
- congestive heart failure
- corneal opacity
- decreased cardiac output
- decreased fetal size
- decreased heart rate
- decreased hepatocyte proliferation
- decreased ventral retina size
- decreased ventricle muscle contractility
- delayed hepatic development
- dermal cysts
- dilated heart atrium
- dilated heart right ventricle
- diluted coat color
- double outlet right ventricle
- edema
- failure of atrioventricular cushion closure
- heart block
- kyphosis
- lethality throughout fetal growth and development complete penetrance
- lethality throughout fetal growth and development incomplete penetrance
- mitral valve atresia
- mitral valve stenosis
- muscular ventricular septal defect
- pallor
- perinatal lethality complete penetrance
- persistent hyperplastic primary vitreous
- persistent truncus arteriosis
- postnatal lethality incomplete penetrance
- prenatal lethality
- pulmonary artery stenosis
- skin edema
- small liver
- thin ventricular wall
- trabecula carnea hypoplasia
- translucent skin
- ventral rotation of lens
- ventricular hypoplasia
- ventricular myocardium compact layer hypoplasia
role in cell
- cell viability
- growth
- apoptosis
- expression in
- activation in
- proliferation
- production in
- invasion by
- migration
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- membrane fraction
- Cytoplasm
- perinuclear region
- Mitochondria
- cytosol
- nucleoplasm
- interchromatin granule clusters
- chromatin
- axons
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rxra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- anatomical structure development
- positive regulation of transcription from RNA polymerase II promoter
- steroid hormone mediated signaling pathway
- hormone-mediated signaling pathway
- positive regulation of thyroid hormone mediated signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- response to retinoic acid
- retinoic acid receptor signaling pathway
- positive regulation of transcription, DNA-dependent
- positive regulation of cholesterol efflux
- cell differentiation
- positive regulation of transporter activity
- positive regulation of vitamin D receptor signaling pathway
- peroxisome proliferator activated receptor signaling pathway
- positive regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- mitochondrion
- cytosol
- receptor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- peptide binding
- sequence-specific DNA binding
- retinoic acid-responsive element binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- retinoic acid binding
- transcription cofactor binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- DBD domain binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- LBD domain binding
- vitamin D response element binding
- vitamin D receptor binding
- steroid hormone receptor activity
- enzyme binding