Prkab1 Gene Summary [Mouse]
Predicted to enable protein kinase activity and protein kinase binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within nail development. Located in nucleus. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system. Orthologous to human PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkab1 |
| Official Name | protein kinase, AMP-activated, beta 1 non-catalytic subunit [Source:MGI Symbol;Acc:MGI:1336167] |
| Ensembl ID | ENSMUSG00000029513 |
| Bio databases IDs | |
| Aliases | protein kinase, AMP-activated, beta 1 non-catalytic subunit |
| Synonyms | 1300015D22Rik, AMPK, AMPK beta 1, AMPK β 1, E430008F22, HAMPKb, protein kinase, AMP-activated, beta 1 non-catalytic subunit, protein kinase AMP-activated non-catalytic subunit beta 1, protein kinase AMP-activated non-catalytic subunit β 1, protein kinase, AMP-activated, β 1 non-catalytic subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkab1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- E_set
- glycogen binding domain
- protein kinase
- Glycogen recognition site of AMP-activated protein kinase
- protein kinase binding
- 5'-AMP-activated protein kinase beta subunit, interaction domain
- protein binding
- SNF1A/AMP-activated protein kinase
Pathways
Biological processes and signaling networks where the Prkab1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiac Fibroblast Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Autophagy
- Chronic Myeloid Leukemia Signaling
- Circadian Rhythm Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- eNOS Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- Mitochondrial Dysfunction
- mTOR Signaling
- Osteoarthritis Pathway
- PPARα/RXRα Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- impaired glucose tolerance
- neoplasia
- obesity
- epithelial cancer
- epithelial neoplasia
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- colorectal adenocarcinoma
phenotypes
- abnormal cholesterol homeostasis
- abnormal epididymis morphology
- abnormal heart left ventricle morphology
- abnormal heart morphology
- abnormal kidney morphology
- abnormal lens morphology
- abnormal response to new environment
- abnormal retina morphology
- abnormal retinal blood vessel morphology
- abnormal retinal blood vessel pattern
- abnormal retinal vasculature morphology
- abnormal sleep behavior
- abnormal spine curvature
- abnormal spleen morphology
- abnormal testis morphology
- abnormal thymus morphology
- abnormal vitreous body morphology
- absent pinna reflex
- anophthalmia
- cataract
- decreased Ly6C-positive immature NK cell number
- decreased body weight
- decreased caudal vertebrae number
- decreased circulating HDL cholesterol level
- decreased circulating LDL cholesterol level
- decreased circulating amylase level
- decreased circulating chloride level
- decreased circulating cholesterol level
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating iron level
- decreased circulating magnesium level
- decreased effector memory T-helper cell number
- decreased erythrocyte cell number
- decreased exploration in new environment
- decreased fasting circulating glucose level
- decreased follicular B cell number
- decreased grip strength
- decreased hematocrit
- decreased hemoglobin content
- decreased kidney weight
- decreased leukocyte cell number
- decreased lung elastance
- decreased lung tissue damping
- decreased lymphocyte cell number
- decreased mean corpuscular hemoglobin
- decreased mean corpuscular hemoglobin concentration
- decreased mean corpuscular volume
- decreased total retina thickness
- developmental and structural abnormality
- enlarged epididymis
- enlarged heart
- enlarged kidney
- enlarged spleen
- enlarged testis
- enlarged thymus
- hyperactivity
- hyperplasia
- hypoactivity
- impaired glucose tolerance
- increased CD4-positive alpha beta T cell number
- increased CD5-positive Ly6C-positive T cell number
- increased Ly6C-positive immature NK cell number
- increased Ly6C-positive mature NK cell number
- increased T cell number
- increased blood uric acid level
- increased circulating bilirubin level
- increased exploration in new environment
- increased fasting circulating glucose level
- increased fluid intake
- increased glycosylated hemoglobin level
- increased heart rate
- increased heart weight
- increased mean platelet volume
- increased memory-marker CD4-negative NK T cell number
- increased memory-marker gamma-delta T cell number
- increased red blood cell distribution width
- increased spleen weight
- kyphosis
- preweaning lethality incomplete penetrance
- shortened QT interval
- shortened RR interval
- shortened ST segment
- abnormal QT interval
- abnormal RR interval
- abnormal astrocyte morphology
- abnormal axon morphology
- abnormal bone marrow morphology
- abnormal cerebellum morphology
- abnormal cerebral cortex morphology
- abnormal circulating HDL cholesterol level
- abnormal circulating LDL cholesterol level
- abnormal circulating amylase level
- abnormal circulating bilirubin level
- abnormal circulating cholesterol level
- abnormal circulating iron level
- abnormal dendrite morphology
- abnormal dentate gyrus morphology
- abnormal ductus venosus morphology
- abnormal erythrocyte cell number
- abnormal erythrocyte morphology
- abnormal erythropoiesis
- abnormal glucose tolerance
- abnormal glycosylated hemoglobin level
- abnormal heart rate
- abnormal hematocrit
- abnormal hemoglobin content
- abnormal hepatocyte physiology
- abnormal inferior vena cava morphology
- abnormal kidney weight
- abnormal lipid level
- abnormal mean corpuscular hemoglobin
- abnormal mean corpuscular hemoglobin concentration
- abnormal mean corpuscular volume
- abnormal myelination
- abnormal neuron differentiation
- abnormal neuronal precursor proliferation
- abnormal optic nerve morphology
- abnormal red blood cell distribution width
- abnormal reticulocyte cell number
- abnormal spleen weight
- abnormal total retina thickness
- absent cerebellar granule layer
- acanthocytosis
- anisocytosis
- astrocytosis
- ataxia
- brain vacuoles
- cerebellum atrophy
- decreased brain size
- decreased cerebellar granule cell number
- decreased circulating interleukin-6 level
- decreased circulating leptin level
- decreased epididymal fat pad weight
- decreased erythrocyte osmotic fragility
- decreased food intake
- decreased liver triglyceride level
- decreased neuron number
- decreased oligodendrocyte number
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to hepatic steatosis
- echinocytosis
- extramedullary hematopoiesis
- hemolytic anemia
- increased circulating erythropoietin level
- increased circulating ferritin level
- increased erythroblast number
- increased erythroid progenitor cell number
- increased insulin sensitivity
- increased spleen iron level
- increased spleen red pulp amount
- loss of hippocampal neurons
- microcytic anemia
- microcytosis
- no abnormal phenotype detected
- optic nerve hypoplasia
- postnatal lethality complete penetrance
- reticulocytosis
- schistocytosis
- seizures
- slow postnatal weight gain
- stomatocytosis
- tremors
role in cell
- growth
- expression in
- phosphorylation in
- production in
- apoptosis
- aggregation
- formation in
- function
- cell death
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkab1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to nutrient levels
- signal transduction
- positive regulation of gene expression
- nail development
- fatty acid biosynthetic process
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- AMP-activated protein kinase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein kinase activity