Ifnar1 Gene Summary [Mouse]
Enables type I interferon binding activity and type I interferon receptor activity. Involved in several processes, including cellular response to interferon-alpha; defense response to other organism; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within T cell activation; positive regulation of cytokine production; and regulation of peptidyl-tyrosine phosphorylation. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in hepatitis C and immunodeficiency 106. Orthologous to human IFNAR1 (interferon alpha and beta receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifnar1 |
| Official Name | interferon (alpha and beta) receptor 1 [Source:MGI Symbol;Acc:MGI:107658] |
| Ensembl ID | ENSMUSG00000022967 |
| Bio databases IDs | |
| Aliases | interferon (alpha and beta) receptor 1 |
| Synonyms | alpha CHAIN of type I IFNR, AVP, Ifar, IFN-alpha-beta-R, IFNalpha/betaR, Ifn-alpha/beta-receptor, IFN alpha/beta receptor 1, IFN-alpha-REC, IFNAR, IFNBR, IFN receptor CHAIN 1, IFN receptor type 1, IFN type 1 receptor, IFN-α-REC, IFN-α-β-R, Ifn-α/β-receptor, IFN α/β receptor 1, IFRC, IMD106, Infar, interferon (alpha and beta) receptor 1, interferon alpha and beta receptor subunit 1, Interferon Receptor, interferon (α and β) receptor 1, interferon α and β receptor subunit 1, LOC284829, type 1 interferon receptor, Type I IFNR, Type I infr, α CHAIN of type I IFNR, β r1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ifnar1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytokine binding
- signal peptide
- Interferon-alpha/beta receptor, fibronectin type III
- protein binding
- JAK pathway signal transduction adaptor
- phosphorylation site
- interferon receptor
- interferon-alpha/beta binding
- cytoplasmic domain
- FN3
- transmembrane domain
- intracellular domain
- interferon-alpha/beta receptor
- Tissue factor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Ifnar1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Dendritic Cell Maturation
- FAK Signaling
- Glucocorticoid Receptor Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Interferon Signaling
- Retinoic acid Mediated Apoptosis Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of PKR in Interferon Induction and Antiviral Response
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- STAT3 Pathway
- Th1 and Th2 Activation Pathway
- Th1 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- psoriasis
- cancer
- multiple sclerosis
- relapsing-remitting multiple sclerosis
- chronic hepatitis B
- hepatitis C
- recurrent melanoma
- plasma cell myeloma
- secondary progressive multiple sclerosis
phenotypes
- abnormal vibrissa morphology
- decreased KLRG1-positive NK cell number
- decreased circulating fructosamine level
- decreased mean platelet volume
- decreased monocyte cell number
- decreased total body fat amount
- improved glucose tolerance
- increased bone mineral content
- increased bone mineral density
- increased circulating creatinine level
- increased lean body mass
- abnormal CD8-positive alpha-beta T cell physiology
- abnormal NK cell physiology
- abnormal circulating creatinine level
- abnormal cytokine level
- abnormal cytokine secretion
- abnormal dendritic cell physiology
- abnormal enzyme/coenzyme activity
- abnormal immunoglobulin level
- abnormal inflammatory response
- abnormal interferon-gamma secretion
- abnormal lean body mass
- abnormal macrophage physiology
- abnormal mononuclear phagocyte morphology
- abnormal osteoclast morphology
- abnormal platelet volume
- abnormal response to infection
- altered susceptibility to infection
- corneal vascularization
- decreased Ly6C high monocyte number
- decreased NK cell number
- decreased T cell apoptosis
- decreased bone mineral density
- decreased interferon-alpha secretion
- decreased interferon-beta secretion
- decreased interleukin-6 secretion
- decreased susceptibility to Coronaviridae infection
- decreased tumor necrosis factor secretion
- impaired natural killer cell mediated cytotoxicity
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased circulating alanine transaminase level
- increased circulating interleukin-12 level
- increased incidence of induced tumors
- increased incidence of tumors by chemical induction
- increased leukocyte cell number
- increased susceptibility to Adenoviridae infection
- increased susceptibility to Coronaviridae infection
- increased susceptibility to Coronaviridae infection induced morbidity/mortality
- increased susceptibility to Herpesvirales infection
- increased susceptibility to Herpesvirales infection induced morbidity/mortality
- increased susceptibility to Orthomyxoviridae infection
- increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality
- increased susceptibility to Picornaviridae infection
- increased susceptibility to Picornaviridae infection induced morbidity/mortality
- increased susceptibility to Poxviridae infection
- increased susceptibility to Riboviria infection
- increased susceptibility to Togaviridae infection
- increased susceptibility to Togaviridae infection induced morbidity/mortality
- increased susceptibility to bacterial infection induced morbidity/mortality
- increased tumor growth/size
- liver hemorrhage
role in cell
- expression in
- differentiation
- activation in
- proliferation
- apoptosis
- phosphorylation in
- cell viability
- quantity
- growth
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ifnar1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of JAK-STAT cascade
- response to lipopolysaccharide
- response to virus
- cellular response to interferon-alpha
- cellular response to interferon-beta
- type I interferon-mediated signaling pathway
- JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- late endosome
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- JAK pathway signal transduction adaptor activity
- type I interferon receptor activity
- type I interferon binding
- cytokine binding