Il17rc Gene Summary [Mouse]
Enables signaling receptor binding activity. Involved in defense response to fungus; granulocyte chemotaxis; and positive regulation of interleukin-6 production. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response. Located in cell surface and plasma membrane. Is expressed in hip; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17RC (interleukin 17 receptor C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il17rc |
| Official Name | interleukin 17 receptor C [Source:MGI Symbol;Acc:MGI:2159336] |
| Ensembl ID | ENSMUSG00000030281 |
| Bio databases IDs | |
| Aliases | interleukin 17 receptor C |
| Synonyms | 1110025H02Rik, CANDF9, Gm19850, IL17-RL, interleukin 17 receptor C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il17rc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- interleukin-17 receptor
- SEFIR domain
- protein binding
- Interleukin-17 receptor extracellular region
- receptor binding
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the Il17rc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- FAK Signaling
- Glucocorticoid Receptor Signaling
- IL-17 Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Fibroblasts
- IL-17A Signaling in Gastric Cells
- Molecular Mechanisms of Cancer
- Role of IL-17A in Arthritis
- Role of IL-17A in Psoriasis
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- STAT3 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma formation
- neoplasia
- tumorigenesis
- organismal death
- lung adenocarcinoma
- small cell lung cancer
- familial candidiasis type 9
- rheumatoid arthritis
- experimental autoimmune encephalomyelitis
- psoriasis
role in cell
- binding in
- expression in
- phosphorylation in
- signaling in
- degradation in
- chemotaxis by
- tubulation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il17rc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- granulocyte chemotaxis
- defense response to fungus
- positive regulation of interleukin-6 production
- positive regulation of cytokine production involved in inflammatory response
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding
- receptor binding
- interleukin-17 receptor activity