Myl6b Gene Summary [Mouse]
Predicted to be a structural constituent of muscle. Predicted to be involved in muscle filament sliding and skeletal muscle tissue development. Predicted to be part of myosin II complex. Is expressed in central nervous system; diaphragm; limb mesenchyme; skeletal musculature; and tail paraxial mesenchyme. Orthologous to human MYL6B (myosin light chain 6B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myl6b |
| Official Name | myosin, light polypeptide 6B [Source:MGI Symbol;Acc:MGI:1917789] |
| Ensembl ID | ENSMUSG00000039824 |
| Bio databases IDs | |
| Aliases | myosin, light polypeptide 6B |
| Synonyms | 5730437E04Rik, LOC107987175, MLC1SA, myosin light chain 6B, myosin, light polypeptide 6B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myl6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- structural constituent of muscle
- EF-hand domain pair
- EFh
- protein binding
- motor protein
- EFh_PI-PLC
Pathways
Biological processes and signaling networks where the Myl6b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agranulocyte Adhesion and Diapedesis
- Apelin Cardiomyocyte Signaling Pathway
- Calcium Signaling
- Cardiac Hypertrophy Signaling
- Cdc42 Signaling
- Cellular Effects of Sildenafil (Viagra)
- CXCR4 Signaling
- Ephrin A Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- ILK Signaling
- PAK Signaling
- Phagosome Formation
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
- Thrombin Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myl6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle contraction
- skeletal muscle tissue development
- muscle filament sliding
Cellular Component
Where in the cell the gene product is active
- myosin complex
- extracellular vesicular exosome
- muscle myosin complex
- myosin II complex
- unconventional myosin complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of muscle
- calcium ion binding
- motor activity