Nlrp1a Gene Summary [Mouse]
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and cysteine-type endopeptidase activator activity. Involved in positive regulation of interleukin-1 beta production and response to muramyl dipeptide. Acts upstream of or within defense response to bacterium and programmed necrotic cell death. Predicted to be located in nucleoplasm. Predicted to be part of NLRP1 inflammasome complex and NLRP3 inflammasome complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nlrp1a |
| Official Name | NLR family, pyrin domain containing 1A [Source:MGI Symbol;Acc:MGI:2684861] |
| Ensembl ID | ENSMUSG00000069830 |
| Bio databases IDs | |
| Aliases | NLR family, pyrin domain containing 1A |
| Synonyms | AIADK, CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, Gm14, Gm15, JRRP, KIAA0926, LOC730994, LT629147.4, LT629150.2, LT629153.3, MSPC, NAC, NALP1, Nalp1a, NLR family pyrin domain containing 1, NLR family, pyrin domain containing 1A, Nlrp1a, PP1044, SLEV1, VAMAS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nlrp1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- PAAD/DAPIN/Pyrin domain
- NOD2 winged helix domain
- peptidase
- protein binding activity, bridging
- ATP binding
- Leucine rich repeat
- NACHT domain
- protease activator
- ATPase
- nucleotide-binding domain
- Caspase recruitment domain
- double-stranded RNA binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- signaling receptor activity
- enzyme binding
- FIIND domain
- linker domain
- protein domain specific binding
- enzyme regulator activity
- protein binding
- Function to find
- endopeptidase
- double-stranded DNA binding
- Leucine rich repeat, ribonuclease inhibitor type
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the Nlrp1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- metastatic colorectal cancer
- endometrial cancer
- autoinflammation with arthritis and dyskeratosis
- multiple self-healing palmoplantar carcinomas
- androgenic alopecia
- Crohn disease
- familial multiple sclerosis
- systemic lupus erythematosus
role in cell
- activation in
- cell viability
- apoptosis
- cell death
- production in
- autophagy in
- binding in
- molecular cleavage in
- autophagy
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nlrp1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muramyl dipeptide
- signal transduction
- positive regulation of inflammatory response
- protein homooligomerization
- regulation of apoptotic process
- defense response to bacterium
- pattern recognition receptor signaling pathway
- cellular response to UV-B
- self proteolysis
- apoptotic process
- pyroptosis
- regulation of inflammatory response
- defense response to virus
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- neuron apoptotic process
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- NLRP1 inflammasome complex
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein domain specific binding
- protein binding
- signaling adaptor activity
- double-stranded RNA binding
- double-stranded DNA binding
- peptidase activity
- cysteine-type endopeptidase activator activity involved in apoptotic process
- enzyme binding