Nlrp10 Gene Summary [Mouse]
Predicted to enable ATP hydrolysis activity and GTPase activity. Involved in defense response to fungus; positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; and positive regulation of inflammatory response. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and nucleus. Predicted to be active in cytoplasm. Is expressed in back skin. Orthologous to human NLRP10 (NLR family pyrin domain containing 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nlrp10 |
| Official Name | NLR family, pyrin domain containing 10 [Source:MGI Symbol;Acc:MGI:2444084] |
| Ensembl ID | ENSMUSG00000049709 |
| Bio databases IDs | |
| Aliases | NLR family, pyrin domain containing 10 |
| Synonyms | 6430548I20Rik, CLR11.1, NALP10, Napl10, NLR family pyrin domain containing 10, NLR family, pyrin domain containing 10, NOD8, PAN5, PYNOD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nlrp10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- PAAD/DAPIN/Pyrin domain
- AAA ATPase domain
- NOD2 winged helix domain
- GTPase
- linker domain
- enzyme
- NACHT domain
- ATPase
- AAA domain
- Death Domain Superfamily of protein-protein interaction domains
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Nlrp10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- experimental autoimmune encephalomyelitis
- endotoxin shock response
- Th2-mediated asthma
role in cell
- expression in
- phosphorylation in
- number
- binding in
- function
- priming by
- transport by
- priming
- emigration
- fungal load
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- cytoplasmic face of plasma membrane
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nlrp10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of inflammatory response
- adaptive immune response
- positive regulation of defense response to bacterium
- positive regulation of T-helper 17 type immune response
- positive regulation of interleukin-8 production
- inflammatory response
- activation of innate immune response
- innate immune response
- positive regulation of T-helper 1 type immune response
- positive regulation of interleukin-1 alpha production
- positive regulation of interleukin-6 production
- defense response to fungus
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytoplasm
- cytosol
- internal side of plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- GTPase activity