Fzd6

Predicted to enable Wnt receptor activity; Wnt-protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in Wnt signaling pathway; negative regulation of DNA-binding transcription factor activity; and negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including cell proliferation in midbrain; embryonic morphogenesis; and establishment of body hair planar orientation. Predicted to be located in several cellular components, including apical plasma membrane; apicolateral plasma membrane; and ciliary basal body. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 1. Orthologous to human FZD6 (frizzled class receptor 6). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fzd6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Fzd6 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Fzd6 gene, providing context for its role in the cell.