Il1rapl1 Gene Summary [Rat]
Predicted to enable signaling receptor binding activity. Involved in negative regulation of exocytosis and regulation of neuron projection development. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 21. Orthologous to human IL1RAPL1 (interleukin 1 receptor accessory protein like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il1rapl1 |
| Official Name | interleukin 1 receptor accessory protein-like 1 [Source:RGD Symbol;Acc:727891] |
| Ensembl ID | ENSRNOG00000029663 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor accessory protein-like 1 |
| Synonyms | 6330532G10RIK, C030039N24, IL1R8, IL1RACPL, IL1RAPL, interleukin 1 receptor accessory protein-like 1, LOC100504948, MRX10, MRX21, MRX34, Oligophrenin-4, OPHN4, TIGIRR-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il1rapl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- immunoglobulin domain
- Immunoglobulin like
- SEFIR domain
- Immunoglobulin I-set domain
- protein binding
- receptor binding
- TIR domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il1rapl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- mental retardation
- schizophrenia
- hereditary disorder
- X-linked mental retardation type 21
- cardiovascular disorder
- vitiligo
- X-linked mental retardation
- malaria
- nonsyndromic X-linked mental retardation
role in cell
- accumulation in
- adhesion
- quantity
- assembly
- differentiation
- number
- presynaptic differentiation
- morphology
- transmission
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- postsynaptic region
- cellular membrane
- synaptic membrane
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il1rapl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of dendritic spine morphogenesis
- signal transduction
- neuron differentiation
- presynaptic membrane assembly
- regulation of neuron projection development
- positive regulation of synapse assembly
- negative regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- dendrite
- postsynaptic membrane
- cytoplasm
- plasma membrane
- axon
- cell surface
Molecular Function
What the gene product does at the molecular level
- NAD+ nucleosidase activity
- protein binding
- receptor binding
- interleukin-1 binding