Lta Gene Summary [Mouse]
Predicted to enable cytokine activity. Acts upstream of or within several processes, including lymph node development; positive regulation of immune response; and positive regulation of type II interferon production. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including extraembryonic component; gut; hemolymphoid system; liver; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lta |
| Official Name | lymphotoxin A [Source:MGI Symbol;Acc:MGI:104797] |
| Ensembl ID | ENSMUSG00000024402 |
| Bio databases IDs | |
| Aliases | lymphotoxin A |
| Synonyms | hlb382, LOC103690381, LT, LT-alpha, Ltx, LT-α, LYMPHOTOXIN A, lymphotoxin alpha, lymphotoxin α, TNFB, TNF-beta, TNFSF1, Tnfsf1b, TNF-β, TNLG1E, tumor necrosis factor-β, tumour necrosis factor-beta, tumour necrosis factor-β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lta often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TNF homology domain
- tumor necrosis factor receptor binding
- TNF
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the Lta gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Adrenomedullin signaling pathway
- CD40 Signaling
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Dendritic Cell Maturation
- Erythropoietin Signaling
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- Lymphotoxin β Receptor Signaling
- NF-κB Signaling
- RAR Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- TNFR2 Signaling
- TREM1 Signaling
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- active rheumatoid arthritis
- rheumatoid arthritis
- non-Hodgkin disease
- follicular B-cell or T-cell lymphoma
- metastasis
- cancer
- bleeding
- infection
- epithelial neoplasia
- liver cancer
phenotypes
- abnormal heart morphology
- decreased monocyte cell number
- enlarged heart
- increased bronchoconstrictive response
- increased circulating alkaline phosphatase level
- increased leukocyte cell number
- increased liver weight
- increased lymphocyte cell number
- increased neutrophil cell number
- increased pulmonary ventilation
- abnormal circulating alkaline phosphatase level
- abnormal circulating tumor necrosis factor level
- abnormal class switch recombination
- abnormal cytokine secretion
- abnormal gamma-delta T cell morphology
- abnormal humoral immune response
- abnormal immune serum protein physiology
- abnormal immune system morphology
- abnormal immune system organ morphology
- abnormal leukocyte cell number
- abnormal lymph node morphology
- abnormal lymph node primary follicle morphology
- abnormal lymph organ development
- abnormal lymphocyte cell number
- abnormal lymphocyte morphology
- abnormal lymphopoiesis
- abnormal monocyte cell number
- abnormal mucosa-associated lymphoid tissue morphology
- abnormal neutrophil cell number
- abnormal sleep pattern
- abnormal spleen B cell follicle morphology
- abnormal spleen marginal zone morphology
- abnormal spleen morphology
- abnormal spleen periarteriolar lymphoid sheath morphology
- abnormal spleen white pulp morphology
- abnormal thymus epithelium morphology
- abnormal thymus medulla morphology
- absent Peyer's patches
- absent axillary lymph nodes
- absent brachial lymph nodes
- absent cervical lymph nodes
- absent inguinal lymph nodes
- absent lymph nodes
- absent marginal zone B cells
- absent mesenteric lymph nodes
- absent peripheral lymph nodes
- absent popliteal lymph nodes
- absent spleen germinal center
- absent spleen marginal zone
- decreased IgA level
- decreased IgG level
- decreased IgG1 level
- decreased IgG2a level
- decreased IgG3 level
- decreased NK cell number
- decreased T cell number
- decreased circulating insulin level
- decreased circulating interferon-gamma level
- decreased immunoglobulin level
- decreased interferon-gamma secretion
- decreased sensitivity to induced morbidity/mortality
- decreased spleen white pulp amount
- decreased susceptibility to endotoxin shock
- decreased susceptibility to experimental autoimmune encephalomyelitis
- decreased susceptibility to induced arthritis
- decreased susceptibility to parasitic infection
- decreased transitional stage B cell number
- decreased tumor necrosis factor secretion
- enlarged liver
- enlarged spleen
- hepatic steatosis
- impaired macrophage phagocytosis
- increased B cell number
- increased B-1b cell number
- increased IgM level
- increased body length
- increased body mass index
- increased body weight
- increased heart weight
- increased sensitivity to induced morbidity/mortality
- increased spleen weight
- increased susceptibility to Poxviridae infection
- increased susceptibility to Riboviria infection
- increased susceptibility to bacterial infection
- increased susceptibility to bacterial infection induced morbidity/mortality
- increased susceptibility to diet-induced obesity
- increased susceptibility to injury
- increased susceptibility to parasitic infection
- liver inflammation
- long tibia
- lung inflammation
- small thymus medulla
role in cell
- binding
- phosphorylation in
- proliferation
- expression in
- quantity
- cell death
- apoptosis
- growth
- formation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lta gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of glial cell proliferation
- cell-cell signaling
- response to nutrient
- lymph node development
- response to xenobiotic stimulus
- response to hypoxia
- positive regulation of chronic inflammatory response to antigenic stimulus
- negative regulation of fibroblast proliferation
- positive regulation of interferon-gamma production
- humoral immune response
- positive regulation of apoptotic process
- apoptotic process
- positive regulation of humoral immune response mediated by circulating immunoglobulin
- response to lipopolysaccharide
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor receptor binding
- cytokine activity
- receptor binding