PAIP1 Gene Summary [Human]
The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PAIP1 |
| Official Name | poly(A) binding protein interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16945] |
| Ensembl ID | ENSG00000172239 |
| Bio databases IDs | |
| Aliases | poly(A) binding protein interacting protein 1, PABP-interacting protein 1 |
| Synonyms | poly(A) binding protein interacting protein 1, polyadenylate binding protein-interacting protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PAIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- translation activator
- Ataxin-2 C-terminal region
- MIF4G domain
- protein binding
- translation regulator
- RNA binding
Pathways
Biological processes and signaling networks where the PAIP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- urothelial carcinoma
- urothelial cancer
- breast carcinoma
role in cell
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- polysomes
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PAIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cytoplasmic translation
- negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- mRNA stabilization
- regulation of translational initiation
- translational initiation
- CRD-mediated mRNA stabilization
- viral protein biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- translation activator activity