Itgae Gene Summary [Mouse]
Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; lymph node; nasal septum; and nucleus pulposus. Orthologous to human ITGAE (integrin subunit alpha E). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Itgae |
| Official Name | integrin alpha E, epithelial-associated [Source:MGI Symbol;Acc:MGI:1298377] |
| Ensembl ID | ENSMUSG00000005947 |
| Bio databases IDs | |
| Aliases | integrin alpha E, epithelial-associated |
| Synonyms | A530055J10, alpha-E1, alpha-M290, aM290, CD103, CD103 antigen, HUMINAE, Integrin Alpha E, integrin alpha E, epithelial-associated, integrin subunit alpha E, integrin subunit α E, Integrin α E, integrin α E, epithelial-associated, Integrin α Iel, Integrin α M290, α-E1, α-M290 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itgae often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MIDAS motif
- Integrin alpha (beta-propellor repeats)
- extracellular domain
- cytoplasmic domain
- von Willebrand factor (vWF) type A domain
- vWFA
- von Willebrand factor type A domain
- FG-GAP repeat
- alpha1 domain
- FG-GAP-like repeat
- A domain
Pathways
Biological processes and signaling networks where the Itgae gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Cdc42 Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HGF Signaling
- Integrin Signaling
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- PAK Signaling
- Paxillin Signaling
- PI3K/AKT Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- infection
- invasive ductal breast cancer
- attention deficit hyperactivity disorder
- pancreatic epithelial cancer
- pancreatic adenocarcinoma
- psoriasis
- Parkinson disease
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
role in cell
- degranulation
- production in
- phosphorylation in
- number
- binding
- adhesion
- retention
- killing
- polarization
- homing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itgae gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- integrin-mediated signaling pathway
- cell adhesion mediated by integrin
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- integrin complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- integrin binding