Ror1 Gene Summary [Mouse]
This gene encodes a receptor tyrosine kinase that has been implicated in nervous system development, specifically in the maintenance of neural progenitor cell fate, neurite extension and synapse formation. The encoded protein, likely a pseudokinase that lacks catalytic activity, may also regulate adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Ror1 |
| Official Name | receptor tyrosine kinase-like orphan receptor 1 [Source:MGI Symbol;Acc:MGI:1347520] |
| Ensembl ID | ENSMUSG00000035305 |
| Bio databases IDs | |
| Aliases | receptor tyrosine kinase-like orphan receptor 1 |
| Synonyms | 2810404D04Rik, dJ537F10.1, NTRKR1, receptor tyrosine kinase-like orphan receptor 1, RGD1559469 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ror1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt-protein binding
- KR
- Protein kinase (unclassified specificity)
- signaling receptor activity
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- Wnt receptor
- Fz domain
- Immunoglobulin I-set domain
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- Immunoglobulin like
- intracellular domain
- Tyrosine kinase, catalytic domain
- Immunoglobulin V-set domain
- coreceptor
Pathways
Biological processes and signaling networks where the Ror1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastasis
- acute myeloid leukemia
- chronic lymphocytic leukemia
- recurrent diffuse large B cell lymphoma
- refractory diffuse large B-cell lymphoma
- mantle cell lymphoma
- relapsed mantle cell lymphoma
- pancreatic carcinoma
role in cell
- expression in
- activation in
- phosphorylation in
- proliferation
- growth
- invasion by
- migration
- molecular cleavage in
- differentiation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- growth cone
- neurites
- actin stress fibers
- filopodia
- perikaryon
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ror1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte development
- inner ear development
- multicellular organismal development
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of NF-kappaB transcription factor activity
- sensory perception of sound
- positive regulation of ERK1 and ERK2 cascade
- Wnt receptor signaling pathway
- positive regulation of kinase activity
- positive regulation of neuron projection development
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- stress fiber
- receptor complex
- plasma membrane
- axon terminus
- cell surface
Molecular Function
What the gene product does at the molecular level
- ATP binding
- coreceptor activity
- Wnt-activated receptor activity
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- Wnt-protein binding