Fas Gene Summary [Mouse]
Enables identical protein binding activity. Involved in circadian rhythm; extrinsic apoptotic signaling pathway via death domain receptors; and positive regulation of protein-containing complex assembly. Acts upstream of or within several processes, including activation-induced cell death of T cells; cellular response to lithium ion; and regulation of hemopoiesis. Located in external side of plasma membrane and extracellular region. Part of CD95 death-inducing signaling complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb segment. Used to study Sjogren's syndrome; autoimmune lymphoproliferative syndrome; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fas |
| Official Name | Fas (TNF receptor superfamily member 6) [Source:MGI Symbol;Acc:MGI:95484] |
| Ensembl ID | ENSMUSG00000024778 |
| Bio databases IDs | |
| Aliases | Fas (TNF receptor superfamily member 6) |
| Synonyms | ALPS1A, APO-1, APT1, CD95, CD95L, CD95 receptor, FAS1, FAS/APO1, Fas cell surface death receptor, FasR, FASTM, lpr, Receptor for Fas Ligand, Receptors for Fas Ligand, TNFR6, Tnf receptor member 6, TNFRSF6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fas often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- cytotoxicity domain
- identical protein binding
- cytoplasmic domain
- ligand-binding domain
- intracellular domain
- transmembrane receptor
- cysteine rich domain
- extracellular domain
- signaling receptor activity
- calmodulin binding
- protease binding
- protein phosphatase binding
- ectodomain
- TNFR/NGFR cysteine-rich region
- protein binding
- Fc domain
- Tumor necrosis factor receptor superfamily (TNFRSF)
- ezrin binding domain
- pre-ligand assembly domain
- binding protein
- kinase binding
- FADD binding domain
- tumor necrosis factor receptor
- transmembrane domain
- cytosolic tail domain
- PDZ binding motif
- Death Domain Superfamily of protein-protein interaction domains
- death domain binding domain
Pathways
Biological processes and signaling networks where the Fas gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Apelin Liver Signaling Pathway
- Apoptosis Signaling
- Aryl Hydrocarbon Receptor Signaling
- Autoimmune Thyroid Disease Signaling
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Chronic Myeloid Leukemia Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Death Receptor Signaling
- Graft-versus-Host Disease Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-4 Signaling
- Induction of Apoptosis by HIV1
- Molecular Mechanisms of Cancer
- Myc Mediated Apoptosis Signaling
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- p53 Signaling
- TEC Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- diabetes mellitus
- non-small cell lung carcinoma
- septic shock
- sepsis
- neoplasia
- plasma cell myeloma
- experimental autoimmune encephalomyelitis
- liver cancer
- epithelial cancer
phenotypes
- CNS inflammation
- abnormal B cell activation
- abnormal B cell morphology
- abnormal B cell receptor editing
- abnormal NK cell physiology
- abnormal T cell clonal deletion
- abnormal T cell differentiation
- abnormal T cell morphology
- abnormal T cell physiology
- abnormal T cell proliferation
- abnormal T-helper 2 physiology
- abnormal airway responsiveness
- abnormal apoptosis
- abnormal cardiovascular system physiology
- abnormal circulating protein level
- abnormal conjunctival epithelium morphology
- abnormal coronary artery morphology
- abnormal cytotoxic T cell physiology
- abnormal enzyme/coenzyme activity
- abnormal gland morphology
- abnormal glomerular capillary endothelium morphology
- abnormal glomerular capillary morphology
- abnormal hepatocyte morphology
- abnormal hypersensitivity reaction
- abnormal immune system morphology
- abnormal immune system organ morphology
- abnormal immune system physiology
- abnormal immunoglobulin level
- abnormal interleukin level
- abnormal kidney morphology
- abnormal kidney physiology
- abnormal leukocyte adhesion
- abnormal leukocyte morphology
- abnormal liver physiology
- abnormal lymph node cell ratio
- abnormal lymph node morphology
- abnormal lymph organ size
- abnormal marginal zone B cell morphology
- abnormal myocardium layer morphology
- abnormal renal glomerulus basement membrane morphology
- abnormal renal glomerulus morphology
- abnormal skin condition
- abnormal spatial learning
- abnormal splenic cell ratio
- abnormal stria vascularis morphology
- abnormal stria vascularis vasculature morphology
- abnormal strial intermediate cell morphology
- abnormal submandibular gland morphology
- abnormal thymus involution
- abnormal thymus medulla morphology
- abnormal thyroid follicle morphology
- abnormal thyroid gland morphology
- abnormal type III hypersensitivity reaction
- abnormal vagina weight
- albuminuria
- autoimmune response
- brain inflammation
- conjunctivitis
- cortical renal glomerulopathies
- decreased B cell apoptosis
- decreased B cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased IgG level
- decreased activated T cell number
- decreased apoptosis
- decreased eosinophil cell number
- decreased hepatocyte apoptosis
- decreased immature B cell number
- decreased interleukin-2 secretion
- decreased macrophage apoptosis
- decreased marginal zone B cell number
- decreased mature B cell number
- decreased neuron apoptosis
- decreased spleen germinal center number
- decreased susceptibility to autoimmune diabetes
- decreased transitional stage B cell number
- demyelination
- dilated renal glomerular capsule
- enlarged Peyer's patches
- enlarged lymph nodes
- enlarged spleen
- enlarged thymus
- epidermal necrosis
- expanded mesangial matrix
- focal hepatic necrosis
- glomerular crescent
- glomerulonephritis
- impaired coordination
- impaired leukocyte tethering or rolling
- increased B cell number
- increased IgA level
- increased IgG level
- increased IgG1 level
- increased IgG2a level
- increased IgG2b level
- increased IgG3 level
- increased IgM level
- increased NK cell number
- increased anti-double stranded DNA antibody level
- increased anti-erythrocyte antigen antibody level
- increased anti-histone antibody level
- increased anti-nuclear antigen antibody level
- increased anti-single stranded DNA antibody level
- increased apoptosis
- increased autoantibody level
- increased blood urea nitrogen level
- increased body weight
- increased central memory CD4-positive alpha-beta T cell number
- increased circulating serum albumin level
- increased circulating total protein level
- increased double-negative T cell number
- increased effector memory CD4-positive alpha-beta T cell number
- increased follicular B cell number
- increased gamma-delta T cell number
- increased immature B cell number
- increased immunoglobulin level
- increased kidney cell proliferation
- increased leukocyte cell number
- increased lymphocyte cell number
- increased marginal zone B cell number
- increased neutrophil cell number
- increased or absent threshold for auditory brainstem response
- increased plasma cell number
- increased renal glomerulus apoptosis
- increased renal glomerulus basement membrane thickness
- increased sensitivity to induced morbidity/mortality
- increased spleen weight
- increased splenocyte number
- increased susceptibility to Picornaviridae infection
- increased susceptibility to autoimmune disorder
- increased susceptibility to bacterial infection
- increased susceptibility to parasitic infection
- increased susceptibility to systemic lupus erythematosus
- increased susceptibility to type III hypersensitivity reaction
- increased thymus weight
- increased transitional stage B cell number
- increased tumor incidence
- increased urine protein level
- joint swelling
- kidney failure
- kidney inflammation
- lacrimal gland atrophy
- lacrimal gland inflammation
- liver hyperplasia
- lymph node hemorrhage
- lymph node hyperplasia
- lymph node necrosis
- lymphoid hyperplasia
- mesangial cell hyperplasia
- no abnormal phenotype detected
- podocyte foot process effacement
- premature death
- renal cast
- renal glomerular immunoglobulin deposits
- renal glomerular protein deposits
- renal glomerulus hypertrophy
- ruffled hair
- salivary gland inflammation
- skin lesions
- submandibular gland inflammation
- thymus atrophy
- thymus cortex atrophy
- thyroid gland inflammation
- vascular inflammation
- vasculitis
role in cell
- expression in
- activation
- inhibition in
- migration
- cell death
- activation in
- molecular cleavage in
- proliferation
- binding in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- soluble fraction
- Golgi-enriched fraction
- membrane fraction
- insoluble fractions
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- membrane surface
- cellular membrane
- cytosol
- sarcoplasm
- basolateral cell surfaces
- plasma membrane extracellular face
- apical membrane
- nuclear bodies
- neurites
- sarcolemma
- anchoring junction
- secretory granules
- membrane rafts
- membrane processes
- perikaryon
- axons
- cell-cell adherens junctions
- plasma
- apical processes
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fas gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- signal transduction
- cellular response to amino acid starvation
- extrinsic apoptotic signaling pathway
- regulation of apoptotic process
- extrinsic apoptotic signaling pathway in absence of ligand
- activation-induced cell death of T cells
- cellular response to mechanical stimulus
- tumor necrosis factor-mediated signaling pathway
- immune response
- motor neuron apoptotic process
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- positive regulation of protein phosphorylation
- apoptotic process
- regulation of stress-activated MAPK cascade
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- cellular response to hyperoxia
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- nuclear body
- membrane raft
- external side of plasma membrane
- cytosol
- death-inducing signaling complex
- CD95 death-inducing signaling complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- identical protein binding
- protein binding
- tumor necrosis factor-activated receptor activity
- signaling receptor activity
- kinase binding