Ppargc1a Gene Summary [Mouse]
This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Ppargc1a |
| Official Name | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [Source:MGI Symbol;Acc:MGI:1342774] |
| Ensembl ID | ENSMUSG00000029167 |
| Bio databases IDs | |
| Aliases | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha |
| Synonyms | A830037N07RIK, Gm11133, LEM6, LRPGC1, peroxisome proliferative activated receptor, gamma, coactivator 1 alpha, peroxisome proliferative activated receptor, γ, coactivator 1 α, Peroxisome Proliferator-Activating Receptor Gamma Coactivator 1 Alpha, Peroxisome Proliferator-Activating Receptor γ Coactivator 1alpha, Peroxisome Proliferator-Activating Receptor γ Coactivator 1 α, PGC-1, PGC1A, PGC-1alpha, PGC-1(alpha), Pgc-1alpha-a, PGC-1v, PGC-1α, PGC-1(α), Pgco1, PGCvf, PGCvf-1, PPARGC1, PPARGC-1-alpha, PPARGC-1-α, PPARG coactivator 1 alpha, PPARG coactivator 1 α, ppar γ coactivator 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppargc1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arginine serine dipeptide repeat domain
- transcription regulator
- LXXLL motif
- transcription co-activator
- RNA recognition motif
- transcription cofactor
- transcription factor binding
- leucine zipper domain
- chromatin binding
- estrogen receptor binding
- receptor binding domain
- peroxisome proliferator activated receptor binding
- alpha-tubulin binding
- Complexin_NTD
- MEF2 binding domain
- ubiquitin protein ligase binding
- RNA recognition motif (RRM) superfamily
- activation domain
- nuclear receptor domain
- ligand-dependent nuclear receptor interactor
- transcription factor binding domain
- nuclear localization sequence
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA binding
- SR domain
- RNA-binding domain
Pathways
Biological processes and signaling networks where the Ppargc1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Apelin Adipocyte Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cellular Effects of Sildenafil (Viagra)
- Estrogen Receptor Signaling
- FXR/RXR Activation
- LPS/IL-1 Mediated Inhibition of RXR Function
- Mitochondrial Dysfunction
- Osteoarthritis Pathway
- PPAR Signaling
- PPARα/RXRα Activation
- PXR/RXR Activation
- RAR Activation
- Serotonin Receptor Signaling
- Sirtuin Signaling Pathway
- TR/RXR Activation
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- adenoma formation
- neurodegeneration
- Huntington disease
- thrombocytopenia
- colorectal cancer
- kidney carcinoma
- renal cancer
- prostate cancer
phenotypes
- abnormal Bruch membrane morphology
- abnormal basal ganglion morphology
- abnormal blood circulation
- abnormal body weight
- abnormal brainstem morphology
- abnormal brown adipose tissue morphology
- abnormal cellular respiration
- abnormal cerebellum morphology
- abnormal cerebral cortex morphology
- abnormal choriocapillaris morphology
- abnormal choroid vasculature morphology
- abnormal crypts of Lieberkuhn morphology
- abnormal fat cell morphology
- abnormal gluconeogenesis
- abnormal glucose homeostasis
- abnormal hippocampus morphology
- abnormal lipid homeostasis
- abnormal liver physiology
- abnormal locomotor behavior
- abnormal melanosome transport
- abnormal mitochondrial physiology
- abnormal neuron morphology
- abnormal retinal pigment epithelium morphology
- abnormal skeletal muscle fiber morphology
- abnormal small intestinal villus morphology
- anhedonia
- cachexia
- congestive heart failure
- decreased body fat mass
- decreased body length
- decreased body weight
- decreased bone mineral content
- decreased cardiac output
- decreased circulating cholesterol level
- decreased circulating glucose level
- decreased circulating insulin level
- decreased food intake
- decreased gastrocnemius weight
- decreased grip strength
- decreased heart rate
- decreased heart weight
- decreased lean body mass
- decreased liver triglyceride level
- decreased mitochondrial DNA content
- decreased oxygen consumption
- decreased respiratory quotient
- decreased retroperitoneal fat pad weight
- decreased skeletal muscle weight
- decreased soleus weight
- decreased susceptibility to diet-induced obesity
- decreased triglyceride level
- decreased ventricle muscle contractility
- dystonia
- fatigue
- gliosis
- hepatic steatosis
- hyperactivity
- hypoglycemia
- impaired adaptive thermogenesis
- impaired autophagy
- improved glucose tolerance
- increased adrenal gland weight
- increased circulating alkaline phosphatase level
- increased heart weight
- increased incidence of tumors by chemical induction
- increased inflammatory response
- increased insulin sensitivity
- increased interleukin-6 secretion
- increased kidney weight
- increased lung weight
- increased oxygen consumption
- increased percent body fat/body weight
- increased response of heart to induced stress
- increased sensitivity to induced morbidity/mortality
- increased startle reflex
- increased susceptibility to weight gain
- increased thigmotaxis
- increased thymus weight
- increased total body fat amount
- increased tumor growth/size
- limb grasping
- lipofuscinosis
- male infertility
- muscle fatigue
- myoclonus
- oxidative stress
- postnatal lethality incomplete penetrance
- retinal macular degeneration
- retinal photoreceptor degeneration
- short photoreceptor inner segment
- short photoreceptor outer segment
- spongiform encephalopathy
- thrombocytopenia
role in cell
- expression in
- growth
- accumulation in
- cell viability
- quantity
- apoptosis
- phosphorylation in
- activation in
- cell death
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- ribosome
- Mitochondria
- sarcomere
- cytosol
- nucleoplasm
- nuclear bodies
- nuclear speckles
- chromatin
- perikaryon
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppargc1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- respiratory electron transport chain
- response to starvation
- response to dietary excess
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- regulation of circadian rhythm
- transcription initiation from RNA polymerase II promoter
- positive regulation of gluconeogenesis
- negative regulation of neuron apoptotic process
- brown fat cell differentiation
- circadian regulation of gene expression
- positive regulation of fatty acid oxidation
- positive regulation of transcription, DNA-dependent
- negative regulation of smooth muscle cell proliferation
- energy homeostasis
- neuron apoptotic process
- gluconeogenesis
- response to muscle activity
- macromolecular complex assembly
- digestion
- regulation of transcription, DNA-dependent
- cellular respiration
- mRNA processing
- mitochondrion organization
- adipose tissue development
- cellular glucose homeostasis
- fatty acid oxidation
- positive regulation of gene expression
- temperature homeostasis
- cellular response to oxidative stress
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- DNA binding
- ligand-dependent nuclear receptor binding
- transcription cofactor activity
- protein binding
- ubiquitin protein ligase binding
- RNA binding
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- sequence-specific DNA binding
- transcription factor binding