PAK4 Gene Summary

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
PAK4
Official Name
p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059]
Ensembl ID
ENSG00000130669
Bio databases IDs NCBI: 10298 Ensembl: ENSG00000130669
Aliases p21 (RAC1) activated kinase 4
Synonyms
5730488L07Rik,mKIAA1142,p21 (RAC1) activated kinase 4
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein serine/threonine kinase
  • p21 binding domain
  • Protein kinase (unclassified specificity)
  • protein kinase
  • regulatory domain
  • catalytic domain
  • ATP-binding domain
  • Protein tyrosine and serine/threonine kinase
  • protein binding
  • Protein kinase domain
  • integrin binding domain
  • kinase
  • Serine/Threonine protein kinases, catalytic domain
  • kinase domain
  • Protein Kinases, catalytic domain
  • CRIB
  • alphaV integrin-binding domain
  • Tyrosine kinase, catalytic domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • epithelial cancer
  • metastasis
  • diabetic nephropathy
  • liver cancer
  • hepatic steatosis
  • bladder cancer
  • hepatocellular carcinoma
  • COVID-19
  • growth failure
regulated by
  • VIP
  • SCT
  • forskolin
  • VTN
  • CDC42
  • pimavanserin
  • bucladesine
  • WNT3A
  • 4-cyclopentyl-2-(2,5-dimethylbenzylsulfanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
  • SRPK1
regulates
role in cell
  • expression in
  • apoptosis
  • transformation
  • phosphorylation in
  • proliferation
  • growth
  • G2/M phase
  • binding in
  • migration
  • outgrowth

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • focal adhesions
  • Nucleus
  • Golgi Apparatus
  • intercellular junctions
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the PAK4 gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • regulation of MAPK cascade
  • cytoskeleton organization
  • signal transduction
  • protein phosphorylation
  • dendritic spine development
  • positive regulation of angiogenesis
  • regulation of cell growth
  • apoptotic process
  • negative regulation of endothelial cell apoptotic process
  • cellular response to organic cyclic compound
  • cell migration
  • intracellular signal transduction

cellular COMPONENT

Where in the cell the gene product is active
  • adherens junction
  • focal adhesion
  • cytoplasm
  • cytosol
  • Golgi apparatus

molecular FUNCTION

What the gene product does at the molecular level
  • ATP binding
  • protein binding
  • protein kinase activity
  • protein serine/threonine kinase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.