PPP2R2B Gene Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 55-78 copies in cases of SCA12. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | PPP2R2B |
| Official Name | protein phosphatase 2 regulatory subunit Bbeta [Source:HGNC Symbol;Acc:HGNC:9305] |
| Ensembl ID | ENSG00000156475 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2 regulatory subunit Bbeta, PP2A subunit B isoform beta |
| Synonyms | 2900026H06RIK,6330404L05Rik,AU018728,B55BETA,E130009M08RIK,LOC108167376,pp2A,PP2AB55BETA,PP2ABBETA,Pp2a B-β,PP2A-PR55B,PP2APR55BETA,PP2R2B,PPPR2B2,PR2AB55BETA,PR2ABBETA,PR2APR55BETA,PR52B,PR55-BETA,PR55-β,protein phosphatase 2 regulatory subunit Bbeta,protein phosphatase 2, regulatory subunit B, beta,protein PHOSPHATASE 2, REGULATORY subunit B, beta isoform,protein phosphatase 2, regulatory subunit B, β,protein PHOSPHATASE 2, REGULATORY subunit B, β isoform,SCA12 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- phosphoprotein phosphatase
- phosphatase
- protein phosphatase regulator
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the PPP2R2B gene plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Ceramide Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Telomerase Signaling
- Tight Junction Signaling
- WNT/β-catenin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- major depression
- neoplasia
- liver cancer
- pervasive developmental disorder
- breast cancer
- Takayasu arteritis
- spinocerebellar ataxia 12
- early missed abortion
- chickenpox
role in cell
- apoptosis
- survival
- proliferation
- cell cycle progression
- dephosphorylation in
- binding in
- degradation in
- stabilization in
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial outer membrane
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PPP2R2B gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- apoptotic process
cellular COMPONENT
Where in the cell the gene product is active
- cytoskeleton
- mitochondrion
- cytosol
- mitochondrial outer membrane
- protein phosphatase type 2A complex
molecular FUNCTION
What the gene product does at the molecular level
- protein binding
- protein phosphatase regulator activity