Target List
Pluripotency Maintenance Pathway
Cell Surface Receptors
IL6ST (GP130), LIFR
Transcription Factors
STAT3
Fibroblast Growth Factor (FGF) Signaling
Fibroblast Growth Factor Receptors
FGFR1, FGFR2, FGFR3, FGFR4
Transcription Factors
CDX2
Hedgehog Signaling
Receptors & Co-Receptors
PTCH1, DISP3, SMO
Transcription Factors & Cofactors
GLI1, GLI2, GLI3, SUFU
Notch Signaling
Receptors & Co-Receptors
NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PSEN1, PSEN2, PSENEN (PEN2)
Transcription Factors
RBPJL
TGFβ / BMP Signaling
Receptors & Co-Receptors
ACVR1 (ALK2), ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1 (ALK1), AMHR2, BMPR1A (ALK3), BMPR1B (ALK6), BMPR2, ENG (EVI-1), LTBP1, LTBP2, LTBP3, LTBP4, RGMA, TGFBR1 (ALK5), TGFBR2, TGFBR3, TGFBRAP1
Transcription Factors & Cofactors
CREBBP (CBP), E2F5, EP300, RBL1, RBL2, SMAD1 (MADH1), SMAD2 (MADH2), SMAD3 (MADH3), SMAD4 (MADH4), SMAD5 (MADH5), SMAD6, SMAD7, SMAD9, SP1, ZEB2
WNT Signaling
Frizzled Family Members & Other WNT Receptors
FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, LRP5, LRP6, VANGL2
Transcription Factors & Cofactors
BCL9, BCL9L, CTNNB1, LEF1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4 (NFAT3), PYGO2, TCF7, TCF7L1, TCF7L2