Target List
Upregulated in Immunotoxicity
ABCA1, ABCG1, ADH1C, AHSG, APOA5, APOF, C9, F2 (Thrombin), FABP1, GSTA3, HPX, HRG, MARC1, NR5A2, PON1, SERPINA3, VPREB1
Downregulated in Immunotoxicity
APOL3, APOL4, BTNL10, BZRAP1, CCNB2, CDR2, CRIM1, CTSE, GPR17, GYPA, HMGCS1, ISG20, KLF1, KLF2, LYZ, MKI67, SLC7A11, SNCA, TRIM10
Immune Response
AHSG, ANG, C9, CCR5, CEBPB, CTSE, HPX, F2 (Thrombin), FN1, IFI6, JCHAIN, IGSF6, ISG20, KLF2, LAT2, LYZ, PAWR, SERPINA3, SNCA, THBS1 (TSP-1), TLR4, VPREB1
Inflammatory Response
AHSG, APOL3, CCR5, CEBPB, F2 (Thrombin), FN1, SERPINA3, SPP1, TLR4
Drug Metabolism
ADH1C, ALDH8A1, BZRAP1, CYP3A5, GSTA3, MARC1, MT1F, NQO1, PON1
Drug Transporters
ABCA1, ABCG1, SLC25A13, SLC31A1, SLC7A11
Glucocorticoid Signaling
AK4, CEBPB, VLDLR
Heat Shock Response
HSPA1B, HSPA5 (GRP78)
Oxidative Stress
HPX, KLF2, MT1F, NQO1, PON1, SLC7A11, SNCA, SRXN1
Unfolded Protein Response
CEBPB, CHAC1, HSPA1B, HSPA5 (GRP78), TM6SF1, VLDLR
Cell Cycle
CCNB2, CCNG2, FBXO32, FBXO38, KLHL24, MKI67
Channels & Transporters
ABCA1, ABCG1, ATP2B1, CHAC1, KCNQ1, SLC25A13, SLC31A1, SLC7A11
Cytoskeletal Regulators
ANG, GEMIN5, GYPA, HRG, MYH3, PAWR
Cytokine & Chemokine Receptors
ACKR3, CCR5, CRIM1, GPR17, TLR4
Extracellular Matrix (ECM) & Cell Adhesion Molecules
FEZ1, FN1, GPNMB, HRG, SERPINA3, SPP1, THBS1 (TSP-1)
G-Protein Coupled Receptor Signaling
ARRDC3, CCR5, ACKR3, GPR17, GPR18
Lipoprotein Signaling & Cholesterol Metabolism
ABCA1, ABCG1, ALDH8A1, APOA5, APOF, APOL3, APOL4, HMGCS1, VLDLR, VPREB1
Transcription Factors
ATF3, CEBPB, ID1, ID2, KLF1, KLF2, NR5A2, PAWR, TRIM10, ZDHHC14
Other Immunotoxicity Genes
BTNL10, C7orf50, CDR2, FABP1, METAP2, NEU4, PSD3, SNX25, VMP1