dPCR LNA Mutation Assays

For detecting specific DNA sequence mutations related to cancer and oncogenesis

  • Duplex assay design detects mutated and wild-type sequences
  • Choice of FAM + HEX or Atto 550 + ROX fluorescent dye combinations
  • LNA-enhanced primers and probes increase assay specificity and sensitivity
  • Wet-lab tested dPCR assays available for more than 200 targets
  • Suitable for use with circulating tumor DNA, liquid biopsy, FFPE and other tissue samples
  • Intended for use with QIAcuity Probe PCR Kits

Product

Product List7 products

GeneGlobe ID: DMH0000042 | Cat. No.: | dPCR LNA Mutation Assays
dPCR Mutation Assay WT1 21441 Human
AA Mutation: p.R369*
Nucleotide Mutation: c.1105C>T
dPCR wet-lab validated
Product Specification
GeneGlobe ID: DMH0000059 | Cat. No.: | dPCR LNA Mutation Assays
dPCR Mutation Assay WT1 21397 Human
AA Mutation: p.R458*
Nucleotide Mutation: c.1372C>T
dPCR wet-lab validated
Product Specification
GeneGlobe ID: DMH0000058 | Cat. No.: | dPCR LNA Mutation Assays
dPCR Mutation Assay WT1 21434 Human
AA Mutation: p.R462Q
Nucleotide Mutation: c.1385G>A
dPCR wet-lab validated
Product Specification
GeneGlobe ID: DMH0000575 | Cat. No.: | dPCR LNA Mutation Assays
dPCR Mutation Assay WT1 21392 Human
AA Mutation: p.A382Vfs*4
Nucleotide Mutation: c.1141_1144dup
dPCR wet-lab validated
Product Specification
GeneGlobe ID: DMH0000060 | Cat. No.: | dPCR LNA Mutation Assays
dPCR Mutation Assay WT1 27307 Human
AA Mutation: p.S381*
Nucleotide Mutation: c.1142C>A
dPCR wet-lab validated
Product Specification
GeneGlobe ID: DMH0000297 | Cat. No.: | dPCR LNA Mutation Assays
dPCR Mutation Assay WT1 21418 Human
AA Mutation: p.V371Cfs*14
Nucleotide Mutation: c.1110dup
dPCR wet-lab validated
Product Specification
GeneGlobe ID: DMH0000048 | Cat. No.: | dPCR LNA Mutation Assays
dPCR Mutation Assay WT1 27370 Human
AA Mutation: p.D464N
Nucleotide Mutation: c.1390G>A
dPCR wet-lab validated
Product Specification
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Resources

Instrument User Manuals (1)
Quick-Start Protocols (1)
Safety Data Sheets (1)
Application Notes (1)
Digital PCR (dPCR) is a powerful technique that detects and quantifies ultra-rare mutations in a high background of wild-type cfDNA down to 0.1% variant allele frequency. Here, we describe end-to-end manual and automated workflows that enable accurate detection and absolute quantification of ultra-rare PIK3CA variants in cfDNA using the QIAcuity Digital PCR System.
Certificates of Analysis (1)