Target List
Cholestasis
Abcb1a (Mdr1), Abcb4, Abcc2 (Cmoat, Mrp2), Abcc3 (Mlp2, Mrp3), Atp8b1, Icam1, Slc51a, Pdyn, Rdx
Steatosis
Up-Regulated in Steatosis​
Cd36 (QuantiNova Symbol: RGD1565355), Fasn, Lpl, Scd
Down-Regulated in Steatosis​
Ppara, Srebf1
Phospholipidosis
Up-Regulated in Phospholipidosis​
Asah1, Fabp1, Hpn, Lss, Mrps18b, S100a8, Serpina3n, Wipi1
Down-Regulated in Phospholipidosis​
Slc2a3, Tagln
Regulated in Phospholipidosis​
Abcb1a (Mdr1), Timm10b
Hepatotoxicity
Up-Regulated in Hepatotoxicity​
Aldoa, Apex1, Btg2, Casp3, Ccng1, Cryl1, Ddit4l2 (Redd2), Dnajb11, Dnajc3, Gadd45a, Gclc, Gsr, Hmox1, Hyou1, Krt18, Krt8, Nqo1, Pla2g12a, Slc17a3, Txnrd1, Yrdc
Down-Regulated in Hepatotoxicity​
Avpr1a, Bhmt, Car3, Cxcl12, Cyp1a2, Fads1, Fmo1, Hao2, Igfals, Mbl2 (QuantiNova Symbol: AABR07006691.1), Rb1, Thrsp
Regulated in Hepatotoxicity​
Abcb11, Timm10b, Maob, Pygl
Nongenotoxic Hepatocarcinogenicity
Up-Regulated in Nongenotoxic Hepatocarcinogenicity​
Aldoa, Apex1, Btg2, Ccng1, Cdkn1a (Cip1, Waf1), Ddx39a, Krt8, Krt18, Mrps18b, Txnrd1
Necrosis
Up-Regulated in Necrosis​
Cd68, Col4a1, Il6st (Gp130), Ipo4, Map3k6, Nus1, Osmr, Psme3, Serpine1 (Pai-1), Skil, Slc39a6, Cemip2
Down-Regulated in Necrosis​
Cdc14b, Emc9, L2hgdh, Lgr5, Mcm10, Mlxipl (QuantiNova Symbol: AABR07035839.1), Fam214a, Rhbg
Regulated in Necrosis​
Cdkn1a (Cip1, Waf1), Ddx39a