Target List
Immune & Inflammatory Responses
Immunostimulatory Factors
IFNG, IL2, IL12A, IL12B, IL15, TNF
Immunosuppressive Factors
CD274 (PD-L1), CD274 (PD-L1), CSF2 (GM-CSF), CTLA4, CXCL12 (SDF1), CXCL5 (ENA-78, LIX), IDO1 (IDO), IDO1 (IDO), IL10, IL13, IL4, CXCL8 (IL8), MIF, NOS2 (iNOS), PDCD1 (PD1), PDCD1 (PD1), PTGS2 (COX2), TGFB1, VEGFA
Pro-Inflammatory Genes
CCL2 (MCP-1), CCL20 (MIP-3A), IFNG, IL1A, IL1B, IL2, IL6, IL12A, IL12B, IL17A, IL23A, PTGS2 (COX2), TLR4, TNF, VEGFA
Anti-Inflammatory Genes
IL4, IL10, IL13, TGFB1
Enzymatic Modulators of Inflammation & Immunity
AICDA (AID), AICDA (AID), GZMA, GZMB, IDO1 (IDO), IDO1 (IDO), NOS2 (iNOS), PTGS2 (COX2)
Antigen Presentation
HLA-A, HLA-B, HLA-C, MICA, MICB
Chemokines
CCL2 (MCP-1), CCL4 (MIP-1B), CCL5 (RANTES), CCL18 (PARC), CCL20 (MIP-3A), CCL21 (MIP-2), CCL22 (MDC), CCL28, CXCL1 (GRO1, GROa, SCYB1), CXCL2 (GRO2, GROb, SCYB2), CXCL5 (ENA-78, LIX), CXCL9 (MIG), CXCL10 (INP10), CXCL11 (I-TAC, IP-9), CXCL12 (SDF1)
Chemokine Receptors
ACKR3, CCR1, CCR2, CCR4, CCR7, CCR9, CCR10, CXCR1, CXCR2, CXCR3, CXCR4, CXCR5
Interleukins
IL1A, IL1B, IL2, IL4, IL6, CXCL8 (IL8), IL10, IL12A, IL12B, IL13, IL15, IL17A, IL23A
Other Cytokines
KITLG (SCF), KITLG (SCF), MIF, SPP1, TNF, TNFSF10 (TRAIL)
Growth Factors & Receptors
CSF1 (MCSF), CSF2 (GM-CSF), CSF3 (GCSF), EGF, EGFR (ERBB1), IGF1, TGFB1, VEGFA
Signal Transduction
Interferon Signaling
GBP1, IFNG, IL6, IRF1
Interferon-Responsive Genes
CCL2 (MCP-1), CCL5 (RANTES), CXCL9 (MIG), CXCL10 (INP10), GBP1, IRF1, MYD88, STAT1, TLR3, TNFSF10 (TRAIL)
NFκB Targets
BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), CCL2 (MCP-1), CCL5 (RANTES), CSF1 (MCSF), CSF2 (GM-CSF), CSF3 (GCSF), IFNG, CXCL8 (IL8), TNF
STAT Targets
CCL2 (MCP-1), CCL4 (MIP-1B), CCL5 (RANTES), CSF1 (MCSF), CSF2 (GM-CSF), CSF3 (GCSF), CXCL9 (MIG), CXCL10 (INP10), CXCL11 (I-TAC, IP-9), CXCL12 (SDF1), IL1B, IL6, CXCL8 (IL8), IL10, IL17A, IL23A, MYC
Toll-Like Receptor Signaling
TLR2, TLR3, TLR4, MYD88
Transcription Factors
FOXP3, HIF1A, IRF1, MYC, NFKB1, STAT1, STAT3, TP53 (p53)
Apoptosis
Pro-Apoptotic
FASLG (TNFSF6), TNF, TNFSF10 (TRAIL), TP53 (p53)
Anti-Apoptotic
BCL2, BCL2L1 (BCLXL), BCL2L1 (BCLXL), BCL2L1 (BCLXL), MYC, STAT3