Target List
Insulin Receptor-Associated Proteins
Insulin & Receptors
Ins1, Ins2, Insl3, Irs1, Irs2
Insulin-Like Growth Factors & Receptors
Grb10, Igf1r, Igf2, Igfbp1
SH3 / SH2 Adaptor Proteins
Cbl, Gab1, Grb10, Grb2
Other Insulin Receptor-Associated Proteins
Cap1, Dok1, Dok2, Dok3, Frs2, Frs3, Insr, Pdpk1, Ppp1ca, Ptpn1 (Ptp), Shc1
PI3 Kinase Signaling
PI3 Kinase Canoncial Pathway Genes
Akt1, Akt2, Akt3, Eif2b1, Eif4ebp1, Gsk3b, Mtor, Pdpk1, Pik3ca (p110-alpha), Pik3cb, Pik3r1 (PI3KA), Pik3r2, Prkcg, Prkcz
PI3 Kinase Signaling Target Genes
Adra1d, Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Dusp14, G6pc, Hk2, Igfbp1, Pck2, Serpine1 (Pai-1), Slc2a4 (Glut4), Srebf1, Ucp1, Vegfa
MAP Kinase Signaling
MAP Kinase Canoncial Pathway Genes
Araf, Braf, Eif2b1, Grb2, Hras, Kras, Map2k1 (MEK1), Mapk1 (Erk2), Raf1, Rps6ka1, Rras, Rras2, Shc1, Sos1
MAP Kinase Signaling Target Genes
Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Ercc1, Fos, Ldlr, Nos2 (Nos2a, iNos), Ucp1
Primary Insulin Signaling Target Genes
Cebpa, Cebpb, Fos, Gcg, Jun, Lep (Leptin), Prl
Secondary Insulin Signaling Effector Target Genes
Npy, Pck2, Slc2a1, Slc2a4 (Glut4), Tg
PPARγ Targets
Acox1, Aebp1, Cap1, Cebpa, Cebpb, Cfd, Gpd1, Pck2, Pparg, Retn, Slc27a4
SREBP1 Targets
Acaca, Fbp1, G6pc, Gck, Pck2, Pklr
Carbohydrate Metabolism
Glucose Metabolism
Fbp1, G6pc, Gck, Gpd1, Hk2, Ins1, Irs2, Pck2, Pklr, Slc2a1, Slc2a4 (Glut4)
Glycogen Metabolism
G6pc, Gsk3b, Ppp1ca
Carbohydrate Transport
Ins1, Slc2a1, Slc2a4 (Glut4)
Lipid Metabolism
Cholesterol Metabolism
Ldlr, Srebf1
Fatty Acid Metabolism
Acaca, Acox1, Fasn, Slc27a4
Lipid Transport
Ldlr, Slc27a4
Other Lipid Metabolism Genes
Araf, Braf, Ins1, Lep (Leptin), Pparg, Prkcz, Raf1, Shc1
Protein Metabolism
Protein Phosphatases
Dusp14, Ppp1ca, Ptpn1 (Ptp)
Protein Kinases
Akt1, Akt2, Akt3, Araf, Braf, Gsk3b, Igf1r, Insl3, Insr, Map2k1 (MEK1), Mapk1 (Erk2), Pdpk1, Prkcg, Prkcz, Raf1, Rps6ka1
Protein Biosynthesis
Eif2b1, Eif4ebp1, Ldlr, Ppp1ca
Protein Transport
Gsk3b, Hras, Rras2
Other Protein Metabolism Genes
Aebp1, Cbl, Dok1, Dok2, Frs2, Gab1, Grb10, Irs1, Nos2 (Nos2a, iNos), Vegfa
Transcription Factors & Regulators
Transcriptional Regulation
Cebpa, Cebpb, Fos, Jun, Pparg, Srebf1
Transcription Factors
Aebp1, Cbl, Cebpa, Cebpb, Fos, Jun, Klf10, Pparg, Srebf1
Cell Growth & Differentiation
Cell Cycle
Hk2, Hras, Igf1r, Igf2, Kras, Mapk1 (Erk2), Mtor, Vegfa
Cell Proliferation
Gab1, Igf1r, Igf2, Irs2, Npy, Prl, Raf1, Shc1, Vegfa
Growth Factors & Receptors
Gab1, Grb2, Igf1r, Igf2, Igfbp1, Insr, Shc1, Vegfa
Cell Differentiation
Nos2 (Nos2a, iNos), Pparg