Target List
Apoptosis
Akt1, Bcl2, Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Bcl2l1 (Bcl-xl), Casp8 (Flice), Casp9, Faslg
Necrosis
Cyld, Grb2, Mag, Parp2, Pvr, Txnl4b
DNA Damage & Repair
Atm, Brca1, Cdkn1a (Cip1, Waf1), Ercc2 (Xpd), Mdm2, Rad51
Mitochondrial Energy Metabolism
Arrdc3, Asb1, Cyb561d1, Dnajb1, Hspa1a (Hsp70-1), Hspa1b, Slc25a25
Fatty Acid Metabolism (β-Oxidation)
Acadm, Acadvl, Acox1, Cpt1a, Cpt1b, Cpt2
Oxidative Stress & Antioxidant Response
Akr1c2, Fhl2, Gclm, Hmox1, Ncoa7, Nqo1, Slc7a11
Heat Shock Response
Hsf1 (Tcf5), Hsp90b1, Hspa4 (Hsp70), Hspa5 (Grp78), Hspb1 (Hsp27), Hspd1
Endoplasmic Reticulum Stress & Unfolded Protein Response
Adm2, Asns, Dnajb9, Herpud1, Inhbe, Trib3 (Skip3), Uhrf1
Cytochrome P450s & Phase I Drug Metabolism
Cyp1a1, Cyp1a2, Cyp2d4, Cyp2e1, Cyp3a23/3a1
Steatosis
Cd36 (QuantiNova Symbol: RGD1565355), Fasn, Lpl, Ppara, Scd, Srebf1
Cholestasis
Abcb4, Abcc2 (Cmoat, Mrp2), Abcc3 (Mlp2, Mrp3), Atp8b1, Slc51a, Pdyn, Rdx
Phospholipidosis
Asah1, Hpn, Lss, Serpina3n, Slc2a3, Tagln, Wipi1
Immunotoxicity
Adh1, F2 (Thrombin), Hpx, Lyz2, Metap2, Mki67, Nr5a2, Trim10