Target List
Upstream Hippo Signaling Regulators
ACTG1, AMOT, AMOTL1, AMOTL2, CASP3, CRB1, CRB2, CRB3, CSNK1D, CSNK1E, DCHS1, DCHS2, DIAPH2, DLG1, DVL2, FAT1, FAT2, FAT3, FAT4, FJX1, AJUBA, LIMD1, LIX1L, LLGL1, LLGL2, LPP, NF2, RASSF2, RASSF4, SCRIB, WTIP, WWC1, ZDHHC18
Hippo Core Kinase Complex
LATS2, MOB1B, MOB1A, SAV1, STK3, STK4, TAZ, YAP1, MST1, WWTR1
Downstream Mediators of Hippo Signaling
HIPK2, MAPK10 (JNK3), MEIS1, PRKCI, PRKCZ, SMAD1 (MADH1), TEAD1, TEAD2, TEAD3, TEAD4, TP63, TSHZ1, TSHZ2, TSHZ3, WNT1
Hippo Signaling Target Genes
CASP3, CCNE1, CCNE2, MYC, PPP2CB, PPP2R1A, PPP2R2D, PTPN14, RERE
Contact Inhibition
NF2, TAZ, YAP1
Cell Polarity
CRB1, CRB2, CRB3, DCHS1, DCHS2, FAT1, FAT2, FAT3, FAT4, LATS1, LATS2, MST1, SCRIB, STK3, STK4, GPC5, HMCN1, POTEF, TAOK1, TAOK2, TAOK3, TJP1, TJP2, MPDZ, MPP5, NPHP4, PARD3, PARD6G
Scaffolding Proteins
YWHAB, YWHAE, YWHAQ (14-3-3θ), YWHAZ