Oxidative phosphorylation dysfunction is connected to a variety of health challenges. When the process doesn’t function optimally, cells struggle to produce the energy they require, leading to cellular distress and potential damage. This is evident in neurodegenerative diseases like Parkinson's and Alzheimer's, where the energy-intensive brain cells are compromised. Metabolic disorders, such as mitochondrial myopathies, emerge when muscle cells can't generate enough energy. Furthermore, certain cancers have been found to exhibit changes in OXPHOS activity, which can impact tumor growth and resistance to treatments.