Target List
HIF1 & Co-Transcription Factors
ARNT, COPS5, HIF1A, HIF1AN, HIF3A, HNF4A, NCOA1, PER1
Other HIF1 Interactors
APEX1, EGLN1, EGLN2, NFKB1, P4HA1, P4HB, TP53 (p53)
Hypoxia Responsive Genes
Angiogenesis
ADORA2B, ANGPTL4, ANXA2, EGR1, EDN1, EPO, F3, GPI, HMOX1, JMJD6, LOX, MMP9, PGF, PLAU (UPA), SERPINE1 (PAI-1), VEGFA
Coagulation
ALDOA, ANXA2, F10, F3, PLAU (UPA), SERPINE1 (PAI-1), SLC16A3
DNA Damage & Repair
ATR, MIF, NDRG1, RUVBL2
Metabolism
ALDOA, DDIT4 (REDD1), ENO1, ERO1A (ERO1L), GBE1, GPI, GYS1, HK2, LDHA, PDK1, PFKFB3, PFKFB4, PFKL, PFKP, PGK1, PKM, SLC2A1, SLC2A3, TPI1
Regulation of Apoptosis
ADM, BNIP3, BNIP3L, DDIT4 (REDD1), IER3, MIF, NOS3 (eNOS), PIM1
Regulation of Cell Proliferation
ADM, BLM, CCNG2, EGR1, IGFBP3, MET, MIF, MXI1, NAMPT, NOS3 (eNOS), ODC1, PGF, PIM1, TXNIP
Transcription Factors
BHLHE40 (DEC1), FOS, RBPJ, USF2
Transporters, Channels & Receptors
SLC2A1, SLC2A3, SLC16A3, TFRC, VDAC1
Other Hypoxia Responsive Genes
ANKRD37, CA9, CTSA, DNAJC5, EIF4EBP1 (4E-BP1), LGALS3, MAP3K1 (MEKK1)
Pathway Activity Signature Genes
ALDOC, ANGPTL4, ANKRD37, BHLHE40 (DEC1), BNIP3, BNIP3L, CA9, FAM162A, HK2, LDHA, NDRG1, P4HA1, PFKFB4, PGK1, SLC2A3, VEGFA