Target List
Ubiquitin-Activating Enzymes (E1)
ATG7, MOCS3, NAE1, NEDD8, SAE1, UBA1, UBA2, UBA3, UBA5, UBA6, UBE2Z
Ubiquitin-Conjugating Enzymes (E2)
Regulation of Apoptosis
BARD1, BRCA1, TP53 (p53), UBE2Z
Cell Cycle Regulators
ANAPC2, BARD1, BRCA1, CDC34, TP53 (p53), UBE2C, UBE2I
Transcriptional Regulation
BRCA1, TP53 (p53), UBE2K, UBE2W
Other Ubiquitin-Conjugating Enzymes (E2)
ARIH1, BTRC (bTrCP), NEDD8, PRKN, STUB1, TMEM189, UBA6, UBE2A, UBE2B, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E2, UBE2E3, UBE2G1, UBE2G2, UBE2H, UBE2J1, UBE2J2, UBE2L3, UBE2M, UBE2N, UBE2Q1, UBE2R2, UBE2S, UBE2T, UBR2
Ubiquitin-Protein Ligases (E3)
Regulation of Apoptosis
BARD1, BRCA1, CUL1, CUL2, CUL3, CUL4A, CUL5, TP53 (p53), UBE4B, VHL
Cell Cycle Regulators
ANAPC11, ANAPC2, BARD1, BRCA1, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, CUL7, DDB1, MDM2, CUL9, SKP1, SKP2, TP53 (p53), VHL
Transcriptional Regulation
BRCA1, CBL, MDM2, SMURF2, TP53 (p53), VHL, WWP1
Other Ubiquitin-Protein Ligases (E3)
ARIH1, BRCC3, BTRC (bTrCP), DZIP3, FBXO3, FBXO31, FBXO4, FBXW10, FBXW9, HECW1, HECW2, HERC5, HUWE1, MARCH5, MIB1, MUL1, NEDD8, PRKN, COP1, RNF123, RNF148, SMURF1, STUB1, SYVN1, UBE2L3, UBE2T, UBR1, UBR2