Target List
p53 Activation
ATM, ATR, BBC3 (PUMA), BRCA1, CDKN1A (p21CIP1, WAF1), CDKN2A (P16INK4A), CHEK1, CHEK2 (RAD53), FOXO3, GML, MDM2, MSH2, SIRT1, TP63, TP73
p53 Regulators & Interactors
CDKN2A (P16INK4A), DNMT1, HDAC1, KAT2B, MDM2, MDM4, SIRT1, TADA3, TP53AIP1, TP53BP2, TP63, TP73
p53 Targets
Apoptosis
APAF1, BAX, BBC3 (PUMA), BTG2, CASP9, EGFR (ERBB1), EI24, ESR1 (ERα), FAS, PRKCA, TNF, TNFRSF10B (DR5), TP53 (p53), TP53AIP1, TP73
Cell Cycle
CCNG1, CDC25A, CDC25C, CDKN1A (p21CIP1, WAF1), E2F1, E2F3, GML, MDM2, MYC, PPM1D, RB1, RPRM, SESN2, SIAH1
DNA Damage & Repair
BRCA1, BTG2, EGFR (ERBB1), GADD45A, PCNA, PTTG1
Angiogenesis
ADGRB1 (BAI1), IL6, PTEN
Responses Downstream of p53 Signaling
Apoptosis
APAF1, BCL2, BCL2A1 (BFL1), BID, BIRC5, CASP2, CASP9, CRADD, FADD, FASLG (TNFSF6), IGF1R, MCL1, NF1, NFKB1, PIDD1 (PIDD), RELA, TNFRSF10D, TRAF2, WT1
Cell Cycle
CCNB1, CCNE1, CCNG1, CCNH, CDK1, CDK4, PRC1, TSC1
DNA Damage & Repair
BRCA2, MLH1, XRCC5
Transcription Factors & Regulators
BRCA2, EGR1, JUN, MYOD1, NFKB1, RELA, STAT1
Other Responses Downstream of p53 Signaling
HK2, KRAS