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GeneGlobe ID: JHS-003Z | Cat. No.: | QIAseq RNA Fusion XP Panels

QIAseq RNA Fusion XP Lung Cancer Panel

Kit containing ALL reagents (except indexes) for fusion and gene expression profiling by digital RNAseq

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Product Specification

Target List

Covers specific sides of specific exons of the targeted genes based on the Human GRCh38 genome build.Analyzes the expression of the targeted genes.Covers specific hotspots of the targeted genes based on the Human GRCh38 genome build.

Acinar Adenocarcinomas
ALKCD74EML4HIP1KIF5BROS1SDC4
Adenocarcinomas
ALKBAIAP2L1BCL11ABRAFCCDC6CD74CUX1EML4EZRFGFR2FGFR3GCC2GOPCHIP1HLA-DRB1KIAA1217KIF5BKLC1LRIG3METMPRIPNCOA4NRG1 (HGL)NTRK1NTRK2PBX1RETROS1SDC4SLC34A2SND1STARD3NLSTRNTACC3TCF3TFGTPM3TPRTRIM33
Bronchioloalveolar Adenocarcinomas
ALKEML4KLC1PBX1ROS1SDC4TCF3
Inflammatory Myofibroblastic Tumors
ALKCD74EML4EZRGOPCLRIG3ROS1SDC4SLC34A2TPM3
Invasive Mucinous Adenocarcinomas
ALKCD74EML4NRG1 (HGL)SLC3A2
Mixed Adenosquamous Carcinomas
ALKEML4KIF5BRET
Mucoepidermoid Carcinomas
ALKCRTC1EML4MAML2
Non-Small Cell Carcinomas
ALKBCL11ACCDC6CD74CUX1EGFR (ERBB1)EML4EZRGCC2GOPCHIP1KIAA1217KIF5BKLC1LRIG3NCOA4RETROS1SDC4SLC34A2STRNTFGTPM3TPRTRIM33
Non-Small Cell Lung Cancers (NSCLC)
ALKBAG4BAIAP2L1BCL11ACCDC6CD74CLIP4CUX1DNAH5EGFR (ERBB1)EML4ETV6EZRFERFGFR1FGFR3GCC2GLRX5GOPCHIP1HLA-DRB1IRF2BP2KIAA1217KIF5BKLC1LRIG3MAN2A1METMPRIPNCOA4NRG1 (HGL)NTRK1NTRK3RAD51RETROS1RUNX1 (AML1)SDC4SLC34A2SLC3A2SQSTM1STRNTACC3TFGTPM3TPRTRA2BTRIM33VSNL1ALKAMER1APCATMBRAFCDKN2A (P16INK4A)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)FGFR3HRASJAK2KRASMETNFE2L2NRASPDGFRAPIK3CA (p110-alpha)PTENRETSTK11 (LKB1)
Squamous Cell Carcinomas (SCC)
ALKBAIAP2L1CD74EML4FGFR2FGFR3HIP1KIF5BNRG1 (HGL)RETTACC3
Other Carcinomas
ALKBRD4EML4NUTM1
Other Lung Cancers
ARL17ABAG4BAIAP2L1CCDC6CD74CUX1EZRFGFR1FGFR3GOPCIRF2BP2KANSL1KIAA1217KIF5BLRIG3MPRIPNCOA4NRG1 (HGL)NTRK1NUTM1PTPRKRETROS1RSPO3SDC4SLC34A2SLC3A2SQSTM1TACC3TPM3TPRTRIM33WHSC1L1
Commercial Control Samples
ALKBAIAP2L1BRAFCCDC6CD74EGFR (ERBB1)EML4ERGETV6FGFR3KIF5BLMNAMETNCOA4NTRK1NTRK3PAX8PPARGRETROS1SEPT14SLC34A2SLC45A3TACC3TFGTMPRSS2TPM3
Checkpoint Molecules
Inhibitory on Tumor Cells​
CD200CD274 (PD-L1)CD274 (PD-L1)CD48CD80CD86ITGAVITGB3LGALS9MICAMICBPDCD1LG2TNFRSF14VSIR
Stimulatory on Tumor Cells​
CD40 (TNFRSF5)CD40LGCD48CD70CD86ICOSLGTNFRSF9TNFSF14TNFSF4 (OX40L)TNFSF9
Inhibitory on T Cells​
BTLACD160CD200R1CD244CD274 (PD-L1)CD274 (PD-L1)CD28CTLA4HAVCR2KLRC1LAG3LILRB1LILRB3PDCD1 (PD1)PDCD1 (PD1)VSIR
Stimulatory on T Cells​
CD244CD27 (TNFRSF7)CD28CD40 (TNFRSF5)CD40LGICOSTNFRSF14TNFRSF18TNFRSF4 (OX40)TNFRSF9TNFSF14TNFSF9
T Cell Receptor Genes​
CD247CD3DCD3ECD3GTRACTRGC2
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1
Major Histocompatibility Complex II Genes​
CD74HLA-DMAHLA-DMBHLA-DOAHLA-DOBHLA-DPA1HLA-DPB1HLA-DQA1HLA-DQA2HLA-DQB1HLA-DQB2HLA-DRAHLA-DRB1HLA-DRB5IFI30
Other Checkpoint Molecules​
ADORA2ABTNL2CD160CD276CD44CD52CD8AHHLA2IDO1 (IDO)IDO1 (IDO)IDO2KIR3DL1KLRD1LAIR1MS4A1NRP1TIGITTMIGD2TNFRSF25 (DR3)TNFRSF8TNFSF15VTCN1
Checkpoint Blockade Therapy Biomarkers
BTLACD274 (PD-L1)CD274 (PD-L1)CD80CD8ACSF2 (GM-CSF)CXCL11 (I-TAC, IP-9)HAVCR2HLA-DRAHLA-DRB1HLA-DRB5ICOSIFNGLAG3PDCD1 (PD1)PDCD1 (PD1)PDCD1LG2
Immuno Regulatory Gene Signature
ERBB2 (HER-2, NEU)FASIL5RA (CD125)INHBATNFRSF8TNFSF4 (OX40L)TNFSF9
Immuno Stimulatory Gene Signature
CD160CD19CD200CD27 (TNFRSF7)CD44CTLA4HLA-AIL12RB2IL17AKIT (CD117)TNFRSF17
Immuno Suppressive Gene Signature
CD274 (PD-L1)CD274 (PD-L1)CD276HAVCR2PDCD1LG2TGFB1
Upregulated in Cancer Vaccination Response
CCL5 (RANTES)CD3DCD86CD8ACXCL10 (INP10)CXCL9 (MIG)GBP1ICOSIRF1KLRD1PSMB9STAT1
Immune Cell Markers
CD8 T Cells​
CD8ACD8BFLT3LGGZMMPRF1
Th1 Cells​
CCL4 (MIP-1B)CD38CD70CSF2 (GM-CSF)CTLA4DPP4IFNGIL12RB2LTA (TNFB)STAT4TBX21
Th17 Cells​
IL17AIL17RARORC
Th2 Cells​
CXCR6GATA3IL26LAIR2MAFPMCHSMAD2 (MADH2)STAT6
Follicular Helper T Cells​
BCL6CXCL13MAFPDCD1 (PD1)PDCD1 (PD1)
Other T Helper Cell Markers​
ANP32BBATFCD28ICOSNUP107
Regulatory T Cells​
FOXP3
Gamma Delta T Cells​
CD160FEZ1TRGC1
Central Memory T Cells​
ATMDOCK9FYB1NEFLREPS1TXKUSP9Y
Effector Memory T Cells​
AKT3CCR2EWSR1IL15RALTKNFATC4 (NFAT3)
Other T Cell Markers​
CD2CD247CD3DCD3ECD3GCD6IL2RBTNFRSF25 (DR3)TRACTRGC2
Myeloid Derived Suppressor Cells​
TGFB1
Cytotoxic Lymphocytes​
CD3ECD3GCD8ACD8BEOMESGZMAGZMBIFNGKLRC1KLRD1NKG7TBX21
Natural Killer Cells​
BCL2CD160FOXJ1FUT5GTF3C1GZMBIL21RKIR3DL1MPPED1NCR1PLA2G6RRADZNF205
Activated Dendritic Cells​
CCL1 (I-309)EBI3LAMP3OAS3
Immature Dendritic Cells​
CD1ACD1BCD1EF13A1SYT17
Myeloid Dendritic Cells​
CD1ACD1BCD1E
Plasmacytoid Dendritic Cells​
IL3RA
Other Dendritic Cell Markers​
CCL13 (MCP-4)CCL17 (TARC)CCL22 (MDC)CD209HSD11B1
Macrophages​
APOECCL7 (MCP-3)CD68CHIT1CXCL5 (ENA-78, LIX)MARCOMSR1
Neutrophils​
CSF3R (GM-CSFR)FPR2MME
Eosinophils​
CCR3IL5RA (CD125)PTGDR2 (CRTH2, GPR44)SMPD3THBS1 (TSP-1)
Mast Cells​
CMA1CTSGKIT (CD117)MS4A2PRG2TPSAB1
B Cells​
BANK1BLKCD19CD79ACR2HLA-DOBHLA-DQA1MS4A1PAX5TNFRSF17
Antigen Presenting Cells​
CMKLR1
Regulatory T Cell Gene Signature
CD274 (PD-L1)CD274 (PD-L1)JAK1PDCD1LG2TIGITTNFRSF18TNFRSF4 (OX40)TNFRSF8TNFRSF9
T Cell Trafficking & Infiltration into Tumors
Stimulates T Cell Trafficking & Infiltration into Tumors​
CCL5 (RANTES)CX3CL1CXCL10 (INP10)CXCL9 (MIG)ITGB2SELL (LECAM-1)
Other T Cell Trafficking & Infiltration into Tumors Genes​
CCL17 (TARC)CCL4 (MIP-1B)CCR3CCR6CD274 (PD-L1)CD274 (PD-L1)CD44CSF2 (GM-CSF)CXCL11 (I-TAC, IP-9)CXCL13FOXP3IFNGITGA4 (CD49D)ITGB7LTA (TNFB)PDCD1 (PD1)PDCD1 (PD1)PDCD1LG2PTENTNFRSF25 (DR3)TNFSF14
T Cell Exhaustion
Upregulated in T Cell Exhaustion​
CCL5 (RANTES)CD200CD27 (TNFRSF7)CD69CTLA4CXCL10 (INP10)CXCL13GBP1HLA-DMAHLA-DQA1ICOSIFI16IFNGITGAVTAP1 (ABCB2)TIGITTNFRSF9
Downregulated in T Cell Exhaustion​
TNFRSF25 (DR3)
T Cell Exhaustion Transcriptional Nodes​
BATFTBX21
Responsiveness or Response Biomarkers
Enhanced Expression in Responsive Versus Nonresponsive Cancers​
APPCAPZBCCL4 (MIP-1B)CCL5 (RANTES)CD8ACSNK1ECTLA4CXCL10 (INP10)CXCL11 (I-TAC, IP-9)CXCL9 (MIG)EBI3EHD1GBA2GZMBHLA-DQA1IDO1 (IDO)IDO1 (IDO)IFNGINHBAIRF2NKG7ODF2PHKG2PPIFPRF1SERPINA3SHMT2SIGMAR1SMAD3 (MADH3)TIA1
Suppressed Expression in Responsive Versus Nonresponsive Cancers​
ACTG1BNIP3LCX3CL1FOXN3IFI27JAK1LTA4HNAIPOPTNPRRC2BPTENRBL2TXK
Differentially Expressed in Responsive Versus Nonresponsive Cancers​
ADAM28AKNAAOAHARHGAP9CACNA2D2CARD11CARD16CD109CLEC11ACORO1ACORO1BCXCR4FLT3FMNL1HIVEP1HIVEP2IFI44LIFITM1 (9-27)IGHA1IGHMIGSF6IKZF1ITPKALSM4LST1MAP3K14NFAM1NFKBIL1PLA2G2DPOU2AF1 (OCA-B)PTPRCAPSERPINB9SH3BP5SYTL1TMC8TNFRSF13BTNFRSF19ZFYVE9
Expression Correlates with Positive Objective Response Rates​
CD274 (PD-L1)CD274 (PD-L1)CD276CTLA4HAVCR2IDO1 (IDO)IDO1 (IDO)LAG3PDCD1LG2VTCN1
Upregulated during Treatment​
CD8ACTLA4CXCL10 (INP10)EOMESGZMAGZMBICOSIFNGPRF1
Regulated during Treatment​
IRF1
Pre-Treatment Response Prediction
Predicts Enhanced Response​
ADAM17 (CD156B)MYCRHOCTIMP1
Other Pre-Treatment Response Predictors​
CDK2CDKN2A (P16INK4A)LARGE1NAB2NRAS
Cancer Cell Killing
Inhibits Cancer Cell Killing​
BTLACD274 (PD-L1)CD274 (PD-L1)CD80HAVCR2IDO1 (IDO)IDO1 (IDO)IDO2LAG3MICAMICBPDCD1 (PD1)PDCD1 (PD1)TGFB1VSIRVTCN1
Stimulates Cancer Cell Killing​
IFNG
Antigen Processing & Presentation
Proteasome​
PSMB10PSMB9
Proteases​
IFI30
Endoplasmic Reticulum & Lysosomal Transport​
TAP1 (ABCB2)TAP2 (ABCB3)TAPBPL
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-HMR1
Major Histocompatibility Complex II Genes​
CD74HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5IFI30
Immune Cell Receptors & Co-Receptors​
CD8ACD8BKIR3DL1KLRC1KLRD1
Stimulates Antigen Presentation​
CD40 (TNFRSF5)CD40LG
Interferon Gamma Response
Cytokines & Chemokines​
CCL5 (RANTES)IL15RASTAT1
Major Histocompatibility Complex I Genes​
B2MHLA-AHLA-BHLA-CHLA-EHLA-FHLA-GHLA-H
Major Histocompatibility Complex II Genes​
HLA-DMAHLA-DQA1HLA-DRAHLA-DRB1HLA-DRB5IFI30
RNA Degradation​
OAS3
Transcription Factors​
IRF1IRF2
Other Interferon Gamma Response Genes​
CD44GBP1
Cytosolic DNA-Sensing Pathway
Cytokines & Interferons​
CCL4 (MIP-1B)CCL5 (RANTES)CXCL10 (INP10)
Small Cell Lung Cancers
ALKAMER1ARID1AATMCDKN2A (P16INK4A)CREBBP (CBP)CTNNB1EGFR (ERBB1)FBXW7FGFR1HRASKIT (CD117)KMT2DKRASMETMYCPIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTENRBM10RET
Carcinomas
Acinar Adenocarcinomas​
BRAFEGFR (ERBB1)KRAS
Adenocarcinomas​
AKT1ALKAMER1APCARID1AATMBRAFCDKN2A (P16INK4A)CREBBP (CBP)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)FBXW7FGFR1FGFR2FGFR3HRASJAK2KIT (CD117)KMT2DKRASMAP2K1METMLH1MYCNFE2L2NRASPDGFRAPIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTENRBM10RETSMAD4 (MADH4)STK11 (LKB1)U2AF1
Bronchioalveolar Adenocarcinomas​
CDKN2A (P16INK4A)EGFR (ERBB1)ERBB2 (HER-2, NEU)KRASSTK11 (LKB1)
Giant Cell Carcinomas​
EGFR (ERBB1)
Large Cell Carcinomas​
BRAFCDKN2A (P16INK4A)EGFR (ERBB1)FGFR1FGFR3HRASKRASNRASPIK3CA (p110-alpha)STK11 (LKB1)
Lymphoepithelioma-Like Carcinomas​
EGFR (ERBB1)
Micropapillary Adenocarcinomas​
BRAFEGFR (ERBB1)KRAS
Mixed Adenosquamous Carcinomas​
EGFR (ERBB1)KRASPIK3CA (p110-alpha)STK11 (LKB1)
Mixed Small Cell Carcinoma-Adenocarcinomas​
CREBBP (CBP)EGFR (ERBB1)
Mucoepidermoid Carcinomas​
EGFR (ERBB1)
Oncocytic Adenocarcinomas​
EGFR (ERBB1)KRAS
Other Carcinomas​
ARID1ACTNNB1HRASNRAS
Pleomorphic Carcinomas​
EGFR (ERBB1)KIT (CD117)KRAS
Sarcomatoid Carcinomas​
EGFR (ERBB1)KRAS
Squamous Cell Carcinomas (SCC)​
AKT1ALKAMER1APCARID1AATMBRAFCDKN2A (P16INK4A)CREBBP (CBP)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)FBXW7FGFR1FGFR2FGFR3HRASJAK2KIT (CD117)KMT2DKRASMAP2K1METMLH1MYCNFE2L2NRASPDGFRAPIK3CA (p110-alpha)PIK3R1 (p85-ALPHA)PTENRBM10RETSMAD4 (MADH4)STK11 (LKB1)U2AF1
Terminal Respiratory Unit Type Adenocarcinomas​
EGFR (ERBB1)
Undifferentiated Carcinomas​
EGFR (ERBB1)KRAS
Blastomas
CTNNB1
Carcinoid-Endocrine Tumors
Atypical​
KRASPIK3CA (p110-alpha)
Typical​
PIK3CA (p110-alpha)
Carcinosarcomas
EGFR (ERBB1)
Other Cancer Subtypes
Hyperplasia​
EGFR (ERBB1)KRAS
Mucinous Proliferation​
KRAS
Neoplasms​
EGFR (ERBB1)KRAS

Product Resources

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Resources

Safety Data Sheets (1)
Safety Data Sheets
Kit Handbooks (1)
QIAseq RNA Fusion XP Panel Handbook
PDF (3MB)
Template Files (1)
QIAseq RNA Fusion XP All-in-One Tool
SOFTWARE (884KB)
Certificates of Analysis (1)
Certificates of Analysis
Introducing the QIAseq RNA Fusion XP Lung Cancer Panel, a cutting-edge addition to our QIAseq RNA Fusion XP Panels lineup, specifically designed for {{application}} applications. This premium product offers unparalleled performance for researchers working with Human models. Leveraging advanced technology, the QIAseq RNA Fusion XP Lung Cancer Panel facilitates accurate and reliable results, making it an indispensable tool for your scientific investigations. Whether you're conducting {{application}}, or any other sophisticated analyses, this product from our QIAseq RNA Fusion XP Panels collection ensures optimal efficiency and reproducibility for Human studies. Embrace the future of research with QIAseq RNA Fusion XP Lung Cancer Panel and elevate your work to new heights.
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