Target List
TNF Superfamily Members
Induction of Apoptosis
FASLG (TNFSF6), LTA (TNFB), TNFSF10 (TRAIL), TNFSF14, TNFSF8
Caspase Activation
TNFSF15
Caspase Inhibition
TNFSF14
Anti-Apoptotic
CD40LG, TNF, TNFSF18
Other Apoptosis Genes
CD70, TNFSF9
Inflammatory Response
CD40LG, TNF
NFκB Signaling
FASLG (TNFSF6), TNF, TNFSF10 (TRAIL), TNFSF14, TNFSF15
Other TNF Superfamily Members
LTB, PGLYRP1, TNFSF11 (RANKL), TNFSF12, TNFSF13, TNFSF13B, TNFSF4 (OX40L), PSMG2
TNF Receptor Superfamily Members
Induction of Apoptosis
FAS, TNFRSF10A (TRAIL-R), TNFRSF10B (DR5), TNFRSF19, TNFRSF25 (DR3), CD27 (TNFRSF7), TNFRSF9, TRADD
Caspase Activation
TNFRSF10A (TRAIL-R), TNFRSF10B (DR5)
Caspase Inhibition
CD27 (TNFRSF7)
Anti-Apoptotic
FAS, TNFRSF10D, TNFRSF18, TNFRSF6B, CD27 (TNFRSF7)
Other Apoptosis Genes
CD40 (TNFRSF5), LTBR, NGFR, TNFRSF10C, TNFRSF11B (OPG), TNFRSF12A, TNFRSF14, TNFRSF1A (TNFR1), TNFRSF1B, TNFRSF21
Inflammatory Response
CD40 (TNFRSF5), TNFRSF1A (TNFR1)
NFκB Signaling
CD40 (TNFRSF5), EDA2R, LTBR, TNFRSF10A (TRAIL-R), TNFRSF10B (DR5), TNFRSF1A (TNFR1), CD27 (TNFRSF7), TRADD
JNK / p38 Signaling
EDA2R, TNFRSF19, CD27 (TNFRSF7)
Other TNF Receptor Superfamily Members
TNFRSF11A (RANK), TNFRSF13B, TNFRSF13C, TNFRSF17, RELT, TNFRSF4 (OX40), TNFRSF8
TNFR1 Signaling
Induction of Apoptosis
CASP3, CRADD, FADD, TRADD
Caspases
CASP2, CASP3, CASP8 (FLICE)
Anti-Apoptotic
BAG4, CASP2, TNF
Other Apoptosis Genes
DFFA, PAK1, TNFRSF1A (TNFR1), TRAF2
Inflammatory Response
TNF, TNFRSF1A (TNFR1)
NFκB Signaling
CASP8 (FLICE), FADD, TNF, TNFRSF1A (TNFR1), TRADD
JNK / p38 Signaling
MAP2K4 (MKK4, JNKK1), MAPK8 (JNK1), PAK1
Transcriptional Regulation
JUN, PARP1 (ADPRT1), RB1, TNF, TNFRSF1A (TNFR1)
Other TNFR1 Signaling Genes
ARHGDIB, CAD, AGFG1, LMNA, LMNB1, LMNB2, MADD, MAP3K1 (MEKK1), MAP3K7 (TAK1), PAK2, PRKDC, SPTAN1
TNFR2 Signaling
Induction of Apoptosis
IKBKG, LTA (TNFB), TRAF3
Anti-Apoptotic
NFKB1, TNFAIP3
Other Apoptosis Genes
NFKBIA (IκBα, MAD3), TNFRSF1B, TRAF1, TRAF2
Inflammatory Response
NFKB1
NFκB Signaling
CHUK (IKKα), IKBKB (IKKβ), IKBKG, NFKBIA (IκBα, MAD3), TNFAIP3
Transcriptional Regulation
IKBKB (IKKβ), IKBKG, NFKB1, NFKBIA (IκBα, MAD3)
Other TNFR2 Signaling Genes
DUSP1 (PTPN16), AGFG1, ELP1, MAP3K1 (MEKK1)